Diversity of virulence level phenotype of hypervirulent Klebsiella pneumoniae from different sequence type lineage

BMC Microbiology
Qiucheng ShiYun-song Yu

Abstract

Hypervirulent Klebsiella pneumoniae (hvKP) is emerging around the Asian-Pacific region and it is the major cause of the community-acquired pyogenic liver abscesses. Multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKP) isolates were reported in France, China and Taiwan. However, the international-ally agreed definition for hvKP and the virulence level of hvKP are not clear. In this study, 56 hvKP isolates were collected from March 2008 to June 2012 and investigated by string test, capsule serotyping, multilocus sequence typing (MLST), virulence gene detection and serum resistance assay. Among the 56 K. pneumoniae isolates, 64.3% had the hypermucoviscosity phenotype, meanwhile, 64.3% were the K1 serotype and 19.6% were the K2 serotype. Within the K1 serotype, 94.4% were ST23, and within the K2 serotype, ST65, ST86 and ST375 accounted for the same percentage 27.3%. The serum resistance showed statistically normal distribution. According to the 50% lethal dose of Galleria. mellonella infection model, hvKP isolates were divided into high virulence level group and moderate virulence level group. The ability of each method evaluating the virulence level of hvKP was assessed using the area under the receiver operating cha...Continue Reading

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Citations

Sep 27, 2019·Scientific Reports·Stéphane L BenoitRobert J Maier
Mar 12, 2020·Frontiers in Microbiology·Miklos FuziAkos Toth
Sep 23, 2020·Pathogens and Disease·Monalessa Fábia PereiraDenise Mara Soares Bazzolli
Feb 16, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Xuehuai ShenXiaomiao Hu
May 1, 2021·International Journal of Molecular Sciences·Vanessa AratoFrancesca Micoli
Apr 27, 2021·Frontiers in Microbiology·Jie ZhuHong Du
Jul 13, 2021·Frontiers in Veterinary Science·Baichuan QiZhanqin Zhao
Jul 4, 2020·Acta Microbiologica Et Immunologica Hungarica·Serra ÖrstenCumhur Özkuyumcu

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Software Mentioned

MLST
magA
R
R script
Prism5
GraphPad

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