Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells

Cell Stem Cell
Tiago C LuisKamil R Kranc

Abstract

Hematopoietic stem cells (HSCs) remain quiescent to preserve long-term integrity. In this issue of Cell Stem Cell, Hinge et al. (2020) and Liang et al. (2020) demonstrate that HSCs achieve this by regulating mitochondrial fission and lysosomal activity, suppressing glucose uptake, and maintaining healthy punctate mitochondria with low metabolic activity.

References

Feb 23, 2011·The Journal of Experimental Medicine·Monika MortensenAnna Katharina Simon
Feb 17, 2017·The Journal of Experimental Medicine·Amelie V GuitartKamil R Kranc
Feb 28, 2017·Nature·Theodore T HoEmmanuelle Passegué
Nov 17, 2017·Blood·Gerald de Haan, Seka Simone Lazare
Jan 9, 2018·Current Opinion in Cell Biology·Hans-Willem Snoeck
Dec 26, 2018·Molecular Cell·Hyo Min ChoWoong Sun

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Citations

Sep 10, 2020·The FEBS Journal·Taeko Kobayashi, Ryoichiro Kageyama

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