Diving Into Cabazitaxel's Mode of Action: More Than a Taxane for the Treatment of Castration-Resistant Prostate Cancer Patients

Clinical Genitourinary Cancer
Begoña MelladoOscar Reig

Abstract

Prostate cancer is a molecularly heterogeneous disease, and mechanisms of action of taxanes and potential mechanisms of resistance are not clearly defined. Taxanes are microtubule-stabilizing agents resulting in the slowing or blocking of mitosis at the metaphase-anaphase transition and induction of apoptotic cell death. Taxanes also can inhibit androgen receptor pathway. To date, several factors have been associated with taxane resistance, including alterations in tubulin, the effect of drug efflux pumps, and the dysfunctional regulation of signaling pathways that may be involved in resistance to therapy. Preclinical and clinical data support the distinct activity of cabazitaxel in prostate cancer that may overcome resistance to prior taxanes or hormonal therapies. It is challenging to define the most adequate therapeutic sequence for each patient. Moreover, the identification of molecular markers of resistance may help to select patients for specific therapies.

References

Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Oct 8, 2004·The New England Journal of Medicine·Daniel P PetrylakE David Crawford
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Josep Domingo-DomenechBegoña Mellado
Jan 29, 2008·Current Cancer Drug Targets·Mary Ann Jordan, Kathy Kamath
Sep 3, 2010·Cancer Research·Meng-Lei ZhuNatasha Kyprianou
Sep 9, 2010·Proceedings of the National Academy of Sciences of the United States of America·Philip A WatsonCharles L Sawyers
May 27, 2011·The New England Journal of Medicine·Johann S de BonoUNKNOWN COU-AA-301 Investigators
Sep 3, 2011·Journal of Carcinogenesis·Peter E Lonergan, Donald J Tindall
Oct 27, 2011·Molecular Cancer Therapeutics·Mercedes Marín-AguileraBegoña Mellado
Jul 10, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J MezynskiJ de Bono
Aug 17, 2012·The New England Journal of Medicine·Howard I ScherUNKNOWN AFFIRM Investigators
Sep 19, 2012·Cancer Research·Maria Thadani-MuleroParaskevi Giannakakou
Apr 2, 2013·European Urology·Giuseppe Di Lorenzo, Carlo Buonerba
Apr 17, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patricia VrignaudMarie-Christine Bissery
Jun 1, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A BahlUNKNOWN TROPIC Investigators
Oct 25, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yanjie ShaoYanjiao Wang
Nov 10, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R J van SoestW M van Weerden
Jan 18, 2014·Molecular Cancer Therapeutics·Eiman MukhtarHasan Mukhtar
Feb 22, 2014·Cancer Research·Maria Thadani-MuleroParaskevi Giannakakou
Jun 21, 2014·International Journal of Biological Sciences·Yu ZhaoHaojie Huang
Aug 21, 2014·Neuro-oncology·Emily GirardJames Olson
Oct 30, 2014·The New England Journal of Medicine·Tomasz M Beer, Bertrand Tombal
Nov 8, 2014·Drug Design, Development and Therapy·Patricia VrignaudSunil Gupta
Nov 26, 2014·Nature Communications·Giuseppe GallettiDavid S Rickman
Aug 6, 2015·The New England Journal of Medicine·Christopher J SweeneyRobert S DiPaola

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Ravi A MadanWilliam L Dahut
Annals of Oncology : Official Journal of the European Society for Medical Oncology
C N Sternberg
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
R J van SoestW M van Weerden
© 2021 Meta ULC. All rights reserved