Diving Response in Rats: Role of the Subthalamic Vasodilator Area

Frontiers in Neurology
E V GolanovGavin W Britz


Diving response (DR) is a powerful integrative response targeted toward survival of the hypoxic/anoxic conditions. Being present in all animals and humans, it allows to survive adverse conditions like diving. Earlier, we discovered that forehead stimulation affords neuroprotective effect, decreasing infarction volume triggered by permanent occlusion of the middle cerebral artery in rats. We hypothesized that cold stimulation of the forehead induces DR in rats, which, in turn, exerts neuroprotection. We compared autonomic [AP, heart rate (HR), cerebral blood flow (CBF)] and EEG responses to the known DR-triggering stimulus, ammonia stimulation of the nasal mucosa, cold stimulation of the forehead, and cold stimulation of the glabrous skin of the tail base in anesthetized rats. Responses in AP, HR, CBF, and EEG to cold stimulation of the forehead and ammonia vapors instillation into the nasal cavity were comparable and differed significantly from responses to the cold stimulation of the tail base. Excitotoxic lesion of the subthalamic vasodilator area (SVA), which is known to participate in CBF regulation and to afford neuroprotection upon excitation, failed to affect autonomic components of the DR evoked by forehead cold stimula...Continue Reading


Sep 1, 1975·Acta Physiologica Scandinavica·Arnoldus S Blix
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M D UnderwoodD J Reis
Oct 1, 1991·Journal of the Autonomic Nervous System·G R Gabbott, D R Jones
Sep 27, 1991·Brain Research·W Michael Panneton
Jan 1, 1990·The Japanese Journal of Physiology·P E PaulevW Nakamura
May 1, 1990·Sports Medicine·L Manley
Jul 1, 1990·Journal of the Autonomic Nervous System·W Michael Panneton
Jan 1, 1988·Acta Physiologica Scandinavica·K Schuitema, B Holm
Apr 1, 1966·Physiological Reviews·H T Andersen
May 1, 1970·Respiration Physiology·R ElsnerR E Brooks
Jan 1, 1982·Comparative Biochemistry and Physiology. A, Comparative Physiology·F F Gilbert, N Gofton
Oct 1, 1980·Journal of the Autonomic Nervous System·K J Dormer, H L Stone
Jan 1, 1994·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·B A Gooden
Oct 1, 1993·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·B A Gooden
May 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E V Golanov, D J Reis
Jan 1, 1996·Progress in Brain Research·Patrice G GuyenetY W Li
Oct 8, 1997·Resuscitation·P SuominenK T Olkkola
Oct 24, 1997·Journal of Applied Physiology·M FerrignoC E Lundgren
May 1, 1996·Journal of the International Neuropsychological Society : JINS·H C HuckabeeJ M Williams
Jan 1, 1997·International Review of Neurobiology·D J Reis, E V Golanov
Jan 23, 1998·Annals of Emergency Medicine·A H ChochinovG G Giesbrecht
May 30, 1998·Journal of Neuroscience Methods·T SaitoT Nemoto
Feb 3, 1999·Annual Review of Genetics·M SugiuraM Sugita
Dec 9, 1994·Prehospital and Disaster Medicine·U SchmidtH Tscherne
Mar 15, 2001·Journal of Applied Physiology·U A LeuenbergerL I Sinoway
Mar 20, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·G P OllenbergerN H West
Apr 23, 2002·Intensive Care Medicine·L PerkJ W van't Wout
Jun 6, 2003·Brain Research Bulletin·Clive M BrownMax J Hilz
Aug 23, 2003·Brain Research·Paul F McCulloch, W Michael Panneton
Feb 1, 2005·Scandinavian Journal of Medicine & Science in Sports·G E Foster, A W Sheel
Oct 14, 2006·Annual Review of Physiology·Jan-Marino RamirezArnoldus S Blix
Apr 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Fei DuWei Chen
Jan 31, 2009·Journal of Applied Physiology·Thomas KjeldNiels H Secher
Jan 23, 2010·Journal of Applied Physiology·W Michael PannetonRajko Juric
Feb 19, 2011·Journal of Cardiovascular Medicine·Paolo AlboniLorella Gianfranchi
Sep 24, 2011·Neurosurgery Clinics of North America·Christopher M DeGiorgioIan A Cook
Oct 4, 2011·Journal of Physiology, Paris·Michele PignatelliXavier Leinekugel
Dec 14, 2011·Respiratory Physiology & Neurobiology·W Michael PannetonD Wei Sun
May 9, 2012·Frontiers in Physiology·W Michael PannetonRajko Juric
Sep 18, 2012·Acta Physiologica Hungarica·A TothL Detari
Jan 31, 2014·Frontiers in Physiology·W Michael PannetonQi Gan
Nov 28, 2014·Comprehensive Physiology·Patrice G Guyenet
Jan 28, 2015·Restorative Neurology and Neuroscience·Samuel S ShinC Edward Dixon
May 18, 2016·European Journal of Applied Physiology·Patricia RatmanovaOlga Vinogradova


Nov 1, 2017·Frontiers in Neurology·Cyrill MeuwlyBernhard Schaller
Mar 16, 2018·The Journal of Physiological Sciences : JPS·Mark Stewart

Related Concepts

Local Anesthesia
Heart Rate
Mucous Membrane
Precipitating Factors
Structure of Middle Cerebral Artery

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.