Diving Response in Rats: Role of the Subthalamic Vasodilator Area

Frontiers in Neurology
E V GolanovGavin W Britz

Abstract

Diving response (DR) is a powerful integrative response targeted toward survival of the hypoxic/anoxic conditions. Being present in all animals and humans, it allows to survive adverse conditions like diving. Earlier, we discovered that forehead stimulation affords neuroprotective effect, decreasing infarction volume triggered by permanent occlusion of the middle cerebral artery in rats. We hypothesized that cold stimulation of the forehead induces DR in rats, which, in turn, exerts neuroprotection. We compared autonomic [AP, heart rate (HR), cerebral blood flow (CBF)] and EEG responses to the known DR-triggering stimulus, ammonia stimulation of the nasal mucosa, cold stimulation of the forehead, and cold stimulation of the glabrous skin of the tail base in anesthetized rats. Responses in AP, HR, CBF, and EEG to cold stimulation of the forehead and ammonia vapors instillation into the nasal cavity were comparable and differed significantly from responses to the cold stimulation of the tail base. Excitotoxic lesion of the subthalamic vasodilator area (SVA), which is known to participate in CBF regulation and to afford neuroprotection upon excitation, failed to affect autonomic components of the DR evoked by forehead cold stimula...Continue Reading

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Citations

Nov 1, 2017·Frontiers in Neurology·Cyrill MeuwlyBernhard Schaller
Mar 16, 2018·The Journal of Physiological Sciences : JPS·Mark Stewart

Related Concepts

Ammonia
Local Anesthesia
Electroencephalography
Exertion
Forehead
Heart Rate
Infarction
Mucous Membrane
Precipitating Factors
Structure of Middle Cerebral Artery

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