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Dizocilpine (MK-801) arrests status epilepticus and prevents brain damage induced by soman

Neuropharmacology

Apr 1, 1992

S SparenborgD J Braitman

PMID: 1522953

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Abstract

The involvement of the NMDA receptor in the neurotoxicity induced by soman, an organophosphorus compound which irreversibly inhibits cholinesterase, was studied in guinea pigs. The drug MK-801 (0.5, 1 or 5 mg/kg, i.p.) was given as a pretreatment before a convulsant dose of soman or as ...read more

Mentioned in this Paper

Convulsants
Pseudocholinesterase
Simple Partial Status Epilepticus
N-Methyl-D-Aspartate Receptors
Tissue Specificity
Brain Damage, Chronic
MK-801
Transcription Initiation
Pralidoxime chloride
Dizocilpine
Paper Details
References
  • References14
  • Citations52
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Dizocilpine (MK-801) arrests status epilepticus and prevents brain damage induced by soman

Neuropharmacology

Apr 1, 1992

S SparenborgD J Braitman

PMID: 1522953

DOI:

Abstract

The involvement of the NMDA receptor in the neurotoxicity induced by soman, an organophosphorus compound which irreversibly inhibits cholinesterase, was studied in guinea pigs. The drug MK-801 (0.5, 1 or 5 mg/kg, i.p.) was given as a pretreatment before a convulsant dose of soman or as ...read more

Mentioned in this Paper

Convulsants
Pseudocholinesterase
Simple Partial Status Epilepticus
N-Methyl-D-Aspartate Receptors
Tissue Specificity

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References14
  • Citations52
12345...

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