DJ-1 changes in G93A-SOD1 transgenic mice: implications for oxidative stress in ALS.

Journal of Molecular Neuroscience : MN
Nirit LevDaniel Offen

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive, lethal, neurodegenerative disorder. The causes of ALS are still obscure. Accumulating evidence supports the hypothesis that oxidative stress and mitochondrial dysfunction can be implicated in ALS pathogenesis. DJ-1 plays an important role in the oxidative stress response. The aim of this study was to discover whether there are changes in DJ-1 expression or in DJ-1-oxidized isoforms in an animal model of ALS. We used mutant SOD1(G93A) transgenic mice, a commonly used animal model for ALS. Upregulation of DJ-1 mRNA and protein levels were identified in the brains and spinal cords of SOD1(G93A) transgenic mice as compared to wild-type controls, evident from an early disease stage. Furthermore, an increase in DJ-1 acidic isoforms was detected, implying that there are more oxidized forms of DJ-1 in the CNS of SOD1(G93A) mice. This is the first report of possible involvement of DJ-1 in ALS. Since DJ-1 has a protective role against oxidative stress, it may suggest a possible therapeutic target in ALS.

References

Oct 1, 1995·Annals of Neurology·P J ShawD Mantle
Feb 13, 1997·Biochemical and Biophysical Research Communications·D NagakuboH Ariga
Dec 14, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D LiuL Li
Oct 18, 2000·Free Radical Biology & Medicine·M BogdanovM Cudkowicz
Dec 4, 2003·Biochemical and Biophysical Research Communications·Takanori YokotaHidehiro Mizusawa
Dec 10, 2003·Brain : a Journal of Neurology·Rina BandopadhyayAndrew J Lees
Jan 30, 2004·EMBO Reports·Takahiro TairaHiroyoshi Ariga
Feb 3, 2004·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·Jeff Agar, Heather Durham
Mar 23, 2004·Annals of the New York Academy of Sciences·Natasa JokicJean-Philippe Loeffler
Jun 8, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rosa M Canet-AvilésMark R Cookson
Mar 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Raymond H KimTak W Mak
Apr 5, 2005·Brain Research·Verian BaderChristine C Stichel
Jul 21, 2005·Free Radical Research·Norberto AguirreMikhail B Bogdanov
Sep 6, 2005·Current Biology : CB·Fiona M MenziesKyung-Tai Min
Oct 22, 2005·Annals of Neurology·Grazia AnnesiAldo Quattrone
Jan 5, 2006·Free Radical Research·Aya SekitoHiroyoshi Ariga
Mar 7, 2006·The Journal of Biological Chemistry·Joungil ChoiLian Li
Apr 4, 2006·Muscle & Nerve·Douglas J MahoneyMark A Tarnopolsky
May 23, 2006·Biochimica Et Biophysica Acta·Siân C BarberPamela J Shaw
Oct 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Casey M ClementsJenny P-Y Ting
Feb 27, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Noriyuki ShibataMakio Kobayashi
Aug 25, 2007·Brain : a Journal of Neurology·Ekaterina V IlievaManuel Portero-Otín

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Citations

Mar 23, 2010·Molecular Neurobiology·Albert Y SunGrace Y Sun
Sep 4, 2010·Antioxidants & Redox Signaling·Mark A Wilson
Mar 11, 2010·Science Signaling·Gerasimos P Sykiotis, Dirk Bohmann
Jun 13, 2012·Biological & Pharmaceutical Bulletin·Ismail Ahmed IsmailSu-Hyung Hong
Aug 25, 2012·Neurology Research International·Dan KrakoraMasatoshi Suzuki
Nov 9, 2010·Journal of Molecular Neuroscience : MN·Michal Dadon-NachumDaniel Offen
Mar 1, 2015·Experimental Neurology·Meital Edri-BramiRachel G Lichtenstein
Oct 17, 2013·Journal of Neuropathology and Experimental Neurology·Sarah KnippenbergSusanne Petri
Aug 29, 2013·Oxidative Medicine and Cellular Longevity·Pamela MilaniCristina Cereda
Apr 22, 2015·Journal of Neural Transmission·Dorit TrudlerDan Frenkel
Jun 10, 2017·Expert Reviews in Molecular Medicine·Francisco J Gil-BeaAinara Vallejo-Illarramendi
Apr 22, 2017·Frontiers in Molecular Neuroscience·Melania FilaretiValentina Bonetto
Jan 3, 2018·FEBS Letters·Plamena R Angelova, Andrey Y Abramov
Feb 14, 2015·Journal of Cellular Physiology·Ismail Ahmed IsmailSu-Hyung Hong
Oct 30, 2018·Journal of Alzheimer's Disease : JAD·Yang LeiMei Zheng
Mar 6, 2010·Journal of Neurochemistry·Satoshi YamashitaMakoto Uchino
Apr 4, 2015·Nature Communications·Oren MoscovitzMichal Sharon
Feb 26, 2014·The Journal of Biological Chemistry·Stefania GirottoLuigi Bubacco
Jul 20, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Zichun ZhaoZhenzhong Li
Mar 6, 2016·The Journal of Biological Chemistry·Mariana Fernandez-CaggianoPhilip Eaton
Dec 13, 2016·Cellular and Molecular Neurobiology·Bor Luen Tang
Apr 22, 2010·Journal of Cell Science·Xiang Ming XuSimon Geir Møller
May 21, 2021·PLoS Biology·Koutarou NakamuraTakashi Shichita
Jun 27, 2021·Progress in Neurobiology·Maoxin Huang, Shengdi Chen
Jan 30, 2021·CNS & Neurological Disorders Drug Targets· Rahul, Yasir H Siddique

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