DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis

Cell Death & Disease
Jing ZhouYunlong Lei

Abstract

Metastasis remains a big barrier for the clinical treatment of colorectal cancer (CRC). Our previous proteomics analysis identified DJ-1 as a potential metastasis biomarker of CRC. In this study, we found that DJ-1 was upregulated in CRC. The levels of DJ-1 were closely correlated with the depths of invasion and predicted patient outcome. Enforced expression of DJ-1 could enhance CRC proliferation and metastasis in vitro and in vivo by stimulating Wnt-β-catenin signaling. Specifically, DJ-1-induced β-catenin nuclear translocation stimulated TCF transcription activity, which promoted BMP4 expression for CRC cell migration and invasion, and elevated CCND1 expression for CRC cell proliferation, respectively. Furthermore, DJ-1-induced Wnt signaling activation was dependent on PLAGL2 expression. In conclusion, our study demonstrates that DJ-1 can promote CRC metastasis by activating PLAGL2-Wnt-BMP4 axis, suggesting novel therapeutic opportunities for postoperative adjuvant therapy in CRC patients.

References

Feb 8, 2002·The Journal of Biological Chemistry·Atsushi MizutaniShigeru Taketani
Mar 16, 2005·Cancer Cell·Raymond H KimTak W Mak
Aug 9, 2007·International Journal of Cancer. Journal International Du Cancer·Guillaume ChatelRosita Winkler
Oct 24, 2007·Biochemical and Biophysical Research Communications·Gang ZhengYu-Chung Yang
Apr 23, 2009·International Journal of Cancer. Journal International Du Cancer·Raviprakash T SitaramGöran Roos
Nov 26, 2010·Journal of Molecular Cell Biology·Aiala Lorente-TrigosAriel Ruiz i Altaba
Nov 15, 2011·Apoptosis : an International Journal on Programmed Cell Death·Tracey S Hanks, Katherine A Gauss
Dec 13, 2012·Scientific Reports·Xiangmin LinJing Zhang
Feb 8, 2014·British Journal of Cancer·I A IsmailS-H Hong
Mar 29, 2014·Carcinogenesis·Ryuichiro SekiyaTakeshi Senga
Dec 17, 2014·Biochemical Pharmacology·Ji CaoBo Yang
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jun 15, 2017·Cancer Research·Yuichiro YokoyamaShogo Ehata
Oct 13, 2017·Cancer Research·Shuo HuangPradip Raychaudhuri

❮ Previous
Next ❯

Citations

Jul 16, 2019·Cancer Cell International·Elsa N Garza TreviñoAlejandra Martinez Garza
Jul 9, 2020·International Journal of Molecular Sciences·Susannah HallalKimberley Louise Alexander-Kaufman
Aug 16, 2019·Journal of Experimental & Clinical Cancer Research : CR·Jianghong YanYunlong Lei
Aug 5, 2019·Biomolecular NMR Assignments·Letizia Barbieri, Enrico Luchinat
Oct 18, 2020·Biomedicines·Maria EjmaGjumrakch Aliev
Oct 22, 2020·Cell Death Discovery·Lynsey BurkeAlessandro Rufini
Nov 16, 2020·Immunity, Inflammation and Disease·Kang LinZhengming Zhu
Mar 19, 2021·Frontiers in Cell and Developmental Biology·Rui MaoTongtong Zhang
Aug 18, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Yong Qi LeongKhuen Yen Ng

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation
xenograft
xenografts
RNA-Seq
transfection

Software Mentioned

DAVID
GEPIA

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.