DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway

Oncogene
Atsushi NiidaTetsu Akiyama

Abstract

Wnt signaling plays an important role in embryonic development and tumorigenesis. These biological effects are exerted by activation of the beta-catenin/TCF transcription complex and consequent regulation of a set of downstream genes. TCF-binding elements have been found in the promoter regions of many TCF target genes and characterized by a highly conserved consensus sequence. Utilizing this consensus sequence, we performed an in silico screening for new TCF target genes. Through computational screening and subsequent experimental analysis, we identified a novel TCF target gene, DKK1, which has been shown to be a potent inhibitor of Wnt signaling. Our finding suggests the existence of a novel feedback loop in Wnt signaling.

References

Dec 1, 1987·Clinical Cardiology·M NakatsukaR Kusukawa
May 1, 1997·Developmental Biology·C M HedgepethP S Klein
Jun 5, 1998·Molecular & General Genetics : MGG·D DooijesM A Mortin
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·A de La CosteC Perret
Jan 19, 1999·Annual Review of Cell and Developmental Biology·A Wodarz, R Nusse
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·M ShtutmanA Ben-Ze'ev
Mar 17, 2001·Nature Reviews. Genetics·L A Pennacchio, E M Rubin
Nov 13, 2001·Developmental Cell·M MukhopadhyayH Westphal
Dec 26, 2001·Nucleic Acids Research·Yutaka SuzukiSumio Sugano
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·D YanL T Williams
Jan 26, 2002·Molecular and Cellular Biology·Barbara LustigJürgen Behrens
Apr 18, 2002·Genes & Development·Patrick J PaddisonDouglas S Conklin
Dec 6, 2002·Nature·Y OkazakiUNKNOWN RIKEN Genome Exploration Research Group Phase I & II Team
Mar 15, 2003·Developmental Cell·Alexander AulehlaBernhard G Herrmann
Aug 22, 1964·Nature·T H BATESH SMITH

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Citations

Jul 8, 2010·Journal of Bone and Mineral Metabolism·Hironori HojoUng-il Chung
May 25, 2011·Clinical & Experimental Metastasis·Shizhuo Wang, Shulan Zhang
Sep 13, 2011·Journal of Molecular Histology·Shujun LiQinghua Zhou
Sep 2, 2011·International Journal of Hematology·Teru Hideshima, Kenneth C Anderson
Sep 11, 2013·Journal of Dermatological Science·Insik HwangSunghoi Hong
Dec 24, 2009·The Journal of Biological Chemistry·Vanessa MarfilRoque Bort
Aug 20, 2009·The Journal of Biological Chemistry·Kari N Nejak-BowenSatdarshan P Monga
Oct 20, 2011·The Journal of Biological Chemistry·Yan ChenMing Zhang
Dec 15, 2012·The Journal of Biological Chemistry·Joon-Ho ChoGoberdhan P Dimri
Jul 27, 2011·Stem Cells and Development·Xusheng WangYaojiong Wu
Aug 16, 2011·Current Opinion in Lipidology·Aikaterini TsaousiSarah J George
Apr 23, 2011·Cancer Research·Catrina E KingAnil K Rustgi
Mar 31, 2009·American Journal of Respiratory Cell and Molecular Biology·Melanie Königshoff, Oliver Eickelberg
Oct 6, 2010·Journal of Experimental & Clinical Cancer Research : CR·Youxin ZhouYulun Huang
Oct 25, 2011·PloS One·Lykke PedersenSandeep Krishna
Sep 7, 2013·PloS One·Diane Angonin, Terence J Van Raay

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