Dl-3-N-butylphthalide attenuates ischemic reperfusion injury by improving the function of cerebral artery and circulation

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Chuan QinYongting Wang

Abstract

Dl-3-N-butylphthalide (NBP) is approved in China for the treatment of ischemic stroke. Previous studies have shown that NBP promotes recovery after stroke via multiple mechanisms. However, the effect of NBP on vascular function and thrombosis remains unclear. Here, we aim to study the effect of NBP on vascular function using a rat model of transient middle cerebral artery occlusion (MCAO) and a state-of-the-art high-resolution synchrotron radiation angiography. Eighty SD rats underwent MCAO surgery. NBP (90 mg/kg) was administrated daily by gavage. Synchrotron radiation angiography was used to evaluate the cerebral vascular perfusion, vasoconstriction, and vasodilation in real-time. Neurological scores, brain infarction and atrophy were evaluated. Real-time PCR was used to assess the expression levels of thrombosis and vasoconstriction-related genes. Results revealed that NBP attenuated thrombosis after MCAO and reduced brain infarct and atrophy volume. NBP administrated at 1 and 4 h after MCAO prevented the vasoconstriction of the artery and maintained its diameter at normal level. Administrated at one week after surgery, NBP functioned as a vasodilator in rats after MCAO while displayed no vasodilating effect in sham group. O...Continue Reading

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Citations

Jul 10, 2020·The Journal of International Medical Research·Yanan SunYu Qin
Jan 27, 2019·Translational Stroke Research·Liping WangGuo-Yuan Yang
Jan 30, 2021·Frontiers in Cellular Neuroscience·Muyassar MamtilahunGuo-Yuan Yang
Jul 17, 2020·Journal of Medicinal Chemistry·José Marco-Contelles, Yihua Zhang

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Methods Mentioned

BETA
X-ray
PCR

Software Mentioned

SPSS Statistics
ARRIVE
ImageJ
Image J

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