Abstract
As microglial activation is a key factor in the pathogenesis of Parkinson's disease (PD), drugs that target this process may help to prevent or delay the development of PD. The present study investigated the effects of dl‑3‑n‑butylphthalide (NBP) on microglia in a lipopolysaccharide (LPS)-induced PD mouse model. The mice were randomly divided into a blank control group, LPS control group and NBP + LPS treatment group. Mice in the treatment group were given an intragastric infusion of 120 mg/kg NBP daily for 30 days during the establishment of the PD mouse model. At 4 and 28 weeks post‑treatment, the motor behaviours of the mice in each group were observed using the rotarod test and the open field test. In addition, immunohistochemical staining was performed to determine the levels of activated microglia, tumour necrosis factor‑α and α‑synuclein, and the number of tyrosine hydroxylase (TH)‑positive cells in the substantia nigra. NBP significantly improved dyskinesia, reduced microglial activation, decreased nuclear α‑synuclein deposition and increased the survival of TH‑positive cells in the substantia nigra of LPS‑induced PD model mice. These findings suggested that NBP may exert its therapeutic effect by reducing microglial ac...Continue Reading
References
Dec 15, 1995·Brain Research·D M BronsteinM K McMillian
Jan 5, 2007·Glia·Liya QinFulton T Crews
Jan 22, 2008·Journal of Neuroinflammation·Bin XingGuoying Bing
Mar 24, 2010·Neurology·Joshua J Gagne, Melinda C Power
Oct 22, 2010·Trends in Neurosciences·Lara Lourenço VendaRichard Wade-Martins
Nov 8, 2011·Neuropharmacology·Xinhong FengLiying Cui
May 1, 2012·Molecular Neurobiology·Carla M Lema ToméPatrik Brundin
Oct 10, 2012·Brain, Behavior, and Immunity·Deirdre B HobanEilis Dowd
Jan 1, 2012·Journal of Parkinson's Disease·Daniel S PetersonGammon M Earhart
Jun 6, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Leo P KellyJeffrey H Kordower
Oct 7, 2014·Acta Neuropathologica·Veselin GrozdanovKarin M Danzer
Jun 16, 2015·Acta Pharmacologica Sinica·Kai HuaHui Ji
Jul 25, 2015·Autophagy·Ziv Gan-OrGuy A Rouleau
Sep 18, 2015·Lancet Neurology·Paolo Calabresi, Massimiliano Di Filippo
Feb 15, 2017·Molecular Neurobiology·Qasim Alhadidi, Zahoor A Shah
Mar 6, 2017·Journal of Neuroinflammation·Rosalía Fernández-CalleGonzalo Herradón
Citations
Dec 5, 2019·Biomedical Reports·Rixin LuoWei Bi
Mar 16, 2019·Frontiers in Aging Neuroscience·Yajing ChenYun-Cheng Wu
May 23, 2021·Neurotoxicity Research·Viplav KshirsagarArchana Juvekar
Jul 17, 2020·Journal of Medicinal Chemistry·José Marco-Contelles, Yihua Zhang