PMID: 8598534Jan 1, 1995Paper

DMI-1, a new DNA methyltransferase inhibitor produced by Streptomyces sp. strain No. 560

Journal of Enzyme Inhibition
K SuzukiM Uyeda

Abstract

A new inhibitor of DNA methyltransferase named DMI-1 has been discovered in the culture filtrate of Streptomyces sp. strain No. 560. DMI-1 was purified by extraction with ethyl acetate followed by Diaion HP-20SS and silica gel column chromatography. The structure of DMI-1 was determined to be 8-methylpentadecanoic acid (C16H32O2). DMI-1 is a novel inhibitor of methyltransferase isolated from microorganisms and is structurally different from sinefungin and A9145C which are structural analogs of S-adenosylmethionine (methyl donor). DMI-1 was a strong inhibitor of N6-methyladenine-DNA methyltransferase (M. Eco RI, EC 2.1.1.72) in a noncompetitive manner and its inhibition depended on the pH and temperature in the assay media.

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Citations

Aug 7, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masaru Uyeda
Jan 1, 1996·Journal of Enzyme Inhibition·K SuzukiM Uyeda
Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jan Havlis, Martin Trbusek

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