DMO-CAP inhibits influenza virus replication by activating heme oxygenase-1-mediated IFN response

Virology Journal
Ming ZhongYuhuan Li

Abstract

As a leading cause of respiratory disease, influenza A virus (IAV) infection remains a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapeutic drugs, development of new drugs is urgently required. Flavonoids extracted from Artemisia rupestris L. have an inhibitory effect on virus infections. Despite this fact, the antiviral properties of 6-demethoxy-4'-O-methylcapillarisin (DMO-CAP), one of such flavonoids, against the influenza virus have not been reported. Thus, the aim of this study is to investigate the anti-IAV virus efficacy and antiviral mechanism of DMO-CAP. The inhibitory activity of DMO-CAP against IAV was detected in vitro using viral titers by Western blot analysis, qRT-PCR, and immunofluorescence assays. The mechanism of DMO-CAP against influenza virus was analyzed by Western blot analysis, qRT-PCR, and luciferase assay. DMO-CAP exhibits broad spectrum of antiviral activities against IAV in vitro. Mechanistically, DMO-CAP treatment induced the phosphorylation of p38 mitogen-activated protein kinase (MAPK), JNK MAPK, and ERK MAPK, which led to the activation of Nrf2/heme oxygenase-1 (HO-1) pathway. Then, the up-regulation of HO-1 expression activated the IFN response...Continue Reading

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Citations

Mar 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alena LiskovaPeter Kubatka
May 22, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Peijie ZhangLi Tang
Nov 28, 2021·BMC Complementary Medicine and Therapies·Beixian ZhouXiping Pan

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