Abstract
As a leading cause of respiratory disease, influenza A virus (IAV) infection remains a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapeutic drugs, development of new drugs is urgently required. Flavonoids extracted from Artemisia rupestris L. have an inhibitory effect on virus infections. Despite this fact, the antiviral properties of 6-demethoxy-4'-O-methylcapillarisin (DMO-CAP), one of such flavonoids, against the influenza virus have not been reported. Thus, the aim of this study is to investigate the anti-IAV virus efficacy and antiviral mechanism of DMO-CAP. The inhibitory activity of DMO-CAP against IAV was detected in vitro using viral titers by Western blot analysis, qRT-PCR, and immunofluorescence assays. The mechanism of DMO-CAP against influenza virus was analyzed by Western blot analysis, qRT-PCR, and luciferase assay. DMO-CAP exhibits broad spectrum of antiviral activities against IAV in vitro. Mechanistically, DMO-CAP treatment induced the phosphorylation of p38 mitogen-activated protein kinase (MAPK), JNK MAPK, and ERK MAPK, which led to the activation of Nrf2/heme oxygenase-1 (HO-1) pathway. Then, the up-regulation of HO-1 expression activated the IFN response...Continue Reading
References
Mar 13, 1999·Journal of Ethnopharmacology·J Serkedjieva, S Ivancheva
Sep 3, 1999·The Journal of Biological Chemistry·J AlamJ L Cook
Oct 11, 2001·Gene Therapy·T HashibaY Ishigatubo
Mar 4, 2008·Acta Dermato-venereologica·Chun-Jun YangSen Yang
Jun 17, 2008·Planta medica·Ai-Lin LiuGuan-Hua Du
Jun 26, 2008·Nature Reviews. Immunology·Anthony J Sadler, Bryan R G Williams
Apr 29, 2009·The Journal of Experimental Medicine·Sotiria TzimaGeorge Kollias
Sep 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Palash MandalLaura E Nagy
May 10, 2011·Free Radical Biology & Medicine·Matthew J KesicIlona Jaspers
Apr 12, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nathan W CumminsAndrew D Badley
Apr 11, 2013·Nucleic Acids Research·Atsushi MaruyamaKen Itoh
Jul 5, 2013·Clinical Microbiology Reviews·Sook-San Wong, Richard J Webby
Jul 12, 2013·The New England Journal of Medicine·J Kenneth Baillie, Paul Digard
Jul 28, 2013·Advances in Pharmacology·Erhard van der VriesAlbert Osterhaus
Oct 11, 2013·Journal of Virology·Lindsay Hill-BatorskiYoshihiro Kawaoka
Oct 24, 2013·Antioxidants & Redox Signaling·Travis D HullJames F George
Sep 10, 2014·Clinical and Experimental Immunology·C E BunseB Eiz-Vesper
Aug 8, 2015·Antimicrobial Agents and Chemotherapy·Hussein TraboulsiMartin V Richter
Aug 19, 2015·Parasites & Vectors·Bo WangShirley Luckhart
Apr 25, 2016·Free Radical Biology & Medicine·Lin-Lin MaJian-Dong Jiang
Aug 25, 2016·Scientific Reports·Chin-Kai TsengJin-Ching Lee
Feb 2, 2017·Influenza and Other Respiratory Viruses·Paulina KoszalkaAeron C Hurt
May 26, 2017·Glia·Colleen E KovacsicsDennis L Kolson
Jul 7, 2017·JCI Insight·Hillary A VandervenStephen J Kent
Jul 12, 2017·Influenza and Other Respiratory Viruses·Louise E LansburyJonathan S Nguyen-Van-Tam
Nov 18, 2017·PloS One·Amelia M ClarkDavid J Topham
Nov 23, 2017·Frontiers in Microbiology·Francisco J IbáñezPablo A González
Mar 3, 2018·International Journal of Molecular Sciences·Mohammed Kawser HossainSsang-Goo Cho
Sep 6, 2018·The New England Journal of Medicine·Frederick G HaydenUNKNOWN Baloxavir Marboxil Investigators Group
Nov 13, 2018·Journal of Asian Natural Products Research·Ming ZhongYu-Huan Li
Dec 24, 2018·Virology·Lin-Lin MaYu-Huan Li
Oct 20, 2019·The Lancet Infectious Diseases
Citations
Mar 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alena LiskovaPeter Kubatka
Feb 27, 2021·Frontiers in Nutrition·Francis U UmeoguajuOrish Ebere Orisakwe
May 22, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Peijie ZhangLi Tang
Nov 28, 2021·BMC Complementary Medicine and Therapies·Beixian ZhouXiping Pan