Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes

Development
Daijiro KonnoFumio Matsuzaki

Abstract

The spatiotemporal identity of neural progenitors and the regional control of neurogenesis are essential for the development of cerebral cortical architecture. Here, we report that mammalian DM domain factors (Dmrt) determine the identity of cerebral cortical progenitors. Among the Dmrt family genes expressed in the developing dorsal telencephalon, Dmrt3 and Dmrta2 show a medialhigh/laterallow expression gradient. Their simultaneous loss confers a ventral identity to dorsal progenitors, resulting in the ectopic expression of Gsx2 and massive production of GABAergic olfactory bulb interneurons in the dorsal telencephalon. Furthermore, double-mutant progenitors in the medial region exhibit upregulated Pax6 and more lateral characteristics. These ventral and lateral shifts in progenitor identity depend on Dmrt gene dosage. We also found that Dmrt factors bind to Gsx2 and Pax6 enhancers to suppress their expression. Our findings thus reveal that the graded expression of Dmrt factors provide positional information for progenitors by differentially repressing downstream genes in the developing cerebral cortex.

References

May 13, 1999·Nature Neuroscience·H WichterleA Alvarez-Buylla
Sep 22, 2001·Science·T Fukuchi-Shimogori, E A Grove
Jan 11, 2002·Developmental Biology·T Saito, N Nakatsuji
May 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Todd T Kroll, Dennis D M O'Leary
Jun 13, 2006·Cerebral Cortex·Marc FuccilloGord Fishell
Aug 28, 2007·Developmental Biology·Chang-Soo HongJean-Pierre Saint-Jeannet
Oct 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brian G Rash, Elizabeth A Grove
Jan 30, 2008·Cell Structure and Function·Hiroshi KimuraNaohito Nozaki
Sep 17, 2008·Genes & Development·Sebastian J ArnoldMatthias Groszer
Jan 15, 2009·Nature Reviews. Neuroscience·Jean M Hébert, Gord Fishell
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Jun 30, 2009·Seminars in Cell & Developmental Biology·Renée V HochSam Pleasure
Dec 5, 2009·Proceedings of the National Academy of Sciences of the United States of America·Louis-Jan PilazColette Dehay
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
Sep 18, 2012·PloS One·María Laura CeciJuan A de Carlos
Oct 3, 2012·Cold Spring Harbor Perspectives in Biology·Ben MartynogaFrançois Guillemot
Oct 9, 2012·The Journal of Comparative Neurology·Bei WangJohn L R Rubenstein
Jan 5, 2013·Science·Le CongFeng Zhang
Jul 23, 2013·Nature Protocols·Huaiyu MiPaul D Thomas
Oct 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lisa A EhrmanKenneth Campbell
Mar 13, 2014·Nature Reviews. Genetics·Daria ShlyuevaAlexander Stark
Mar 19, 2014·EMBO Reports·Judith T M L Paridaen, Wieland B Huttner
Aug 26, 2018·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elodie DesmarisEric J Bellefroid

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Citations

Feb 6, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Takako KikkawaNoriko Osumi

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