DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Elodie DesmarisEric J Bellefroid

Abstract

Specification of dorsoventral regional identity in progenitors of the developing telencephalon is a first pivotal step in the development of the cerebral cortex and basal ganglia. Previously, we demonstrated that the two zinc finger doublesex and mab-3 related (Dmrt) genes, Dmrt5 (Dmrta2) and Dmrt3, which are coexpressed in high caudomedial to low rostrolateral gradients in the cerebral cortical primordium, are separately needed for normal formation of the cortical hem, hippocampus, and caudomedial neocortex. We have now addressed the role of Dmrt3 and Dmrt5 in controlling dorsoventral division of the telencephalon in mice of either sex by comparing the phenotypes of single knock-out (KO) with double KO embryos and by misexpressing Dmrt5 in the ventral telencephalon. We find that DMRT3 and DMRT5 act as critical regulators of progenitor cell dorsoventral identity by repressing ventralizing regulators. Early ventral fate transcriptional regulators expressed in the dorsal lateral ganglionic eminence, such as Gsx2, are upregulated in the dorsal telencephalon of Dmrt3;Dmrt5 double KO embryos and downregulated when ventral telencephalic progenitors express ectopic Dmrt5 Conditional overexpression of Dmrt5 throughout the telencephalon...Continue Reading

Citations

Dec 18, 2019·Cerebral Cortex·Leslie RatiéZoltán Molnár
Feb 6, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Takako KikkawaNoriko Osumi
Jul 16, 2019·Frontiers in Zoology·Virginia PanaraRalf Janssen
Jan 11, 2021·Insect Biochemistry and Molecular Biology·Ryota KasaharaMasataka G Suzuki
Feb 20, 2021·Neuroscience Bulletin·Xiaosu LiZhengang Yang
Dec 19, 2021·Proceedings of the National Academy of Sciences of the United States of America·Athéna R YpsilantiJohn L Rubenstein

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