PMID: 9528670Apr 7, 1998Paper

DMSO produces a new subgel phase in DPPC: DSC and X-ray diffraction study

Biochimica Et Biophysica Acta
S Tristram-NagleJ F Nagle

Abstract

Equilibrium phases and the kinetics of subgel phase transformation of dipalmitoylphosphatidylcholine (DPPC) hydrated with mixtures of dimethylsulfoxide (DMSO)/water have been studied using differential scanning calorimetry (DSC) and X-ray diffraction (XRD). The rate of gel-to-subgel transformation is decreased with a small increase in X, the DMSO/water mole fraction, but then speeds up and becomes faster than in pure water by X = 0.16. The DSC scans show multiple subgel peaks, some of which can be attributed to impacted domain growth. For X greater than 0.10, XRD shows that there is a new, stable subgel phase, S, which also accounts for some of the multiplicity of DSC peaks. Our electron density profiles show that the thickness of the bilayer in the S phase is greater than in the usual C subgel phase. We suggest that the S subgel phase is characterized by different headgroup ordering and smaller chain tilt angle than in the C subgel phase. Electron density profiles show that increasing X decreases the water space between bilayers in all phases, subgel, gel and fluid (L alpha). For X = 0.20, a different gel phase is also observed that may be due to subtle changes in the orientation of chain tilt first observed in partially dehyd...Continue Reading

References

Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·V A ParsegianR P Rand
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S A Simon, T J McIntosh
Dec 22, 1988·Biochimica Et Biophysica Acta·L M Crowe, J H Crowe
Nov 17, 1987·Biochemistry·T J McIntoshS A Simon
Jun 1, 1987·Chemistry and Physics of Lipids·P LaggnerA Schuster
Jul 14, 1987·Biochemistry·S Tristram-NagleJ F Nagle
Jul 11, 1985·Biochimica Et Biophysica Acta·W Curatolo
Aug 1, 1984·Chemistry and Physics of Lipids·L Finegold, M A Singer
Aug 3, 1982·Biochemistry·J F Nagle, D A Wilkinson
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S C ChenB J Gaffney
Dec 1, 1994·Bioscience Reports·Z W Yu, P J Quinn
Nov 1, 1993·Journal of Reproduction and Fertility·J Ali, J N Shelton
Apr 20, 1994·Biochimica Et Biophysica Acta·S Tristram-NagleJ F Nagle
Jan 18, 1993·Biochimica Et Biophysica Acta·G L JendrasiakA A Ribeiro
Apr 1, 1993·Biophysical Journal·S Tristram-NagleJ F Nagle
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·W J SunJ F Nagle
May 16, 1959·Nature·J E LOVELOCK, M W BISHOP

❮ Previous
Next ❯

Citations

Jul 28, 2012·The Journal of Membrane Biology·D PinisettyR V Devireddy
Dec 18, 2001·Biophysical Chemistry·H H Chang, P K Dea
Dec 16, 2011·The Journal of Chemical Physics·Aleksandra P DabkowskaSylvia E McLain
Feb 10, 2016·The Journal of Physical Chemistry. a·A GiugliarelliP Sassi
Aug 12, 2015·Proceedings of the National Academy of Sciences of the United States of America·Alex M SchraderJacob N Israelachvili
Jan 24, 2009·Colloids and Surfaces. B, Biointerfaces·Sung-Hee ParkJin-Woong Kim
Apr 20, 2011·Macromolecular Bioscience·Dinesh JagadeesanEugenia Kumacheva
Jul 18, 2006·Biochimica Et Biophysica Acta·Sukit Leekumjorn, Amadeu K Sum
Mar 9, 2005·Chemistry and Physics of Lipids·M SuwalskyK Strzałka
Jan 12, 2005·Chemistry and Physics of Lipids·M A KiselevR H H Neubert
May 8, 1999·Biophysical Journal·A M Smondyrev, M L Berkowitz
Aug 13, 2005·Chemistry and Physics of Lipids·Sathiah ThennarasuAyyalusamy Ramamoorthy
Jul 23, 2015·Biophysical Journal·Chi-Yuan ChengSongi Han
Aug 26, 2004·Biochimica Et Biophysica Acta·Peter Westh
Jul 8, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Aleksandra P DabkowskaChristian D Lorenz
Nov 5, 2016·Biochimica Et Biophysica Acta·Maria RicciPaola Sassi
Nov 8, 2017·Physical Chemistry Chemical Physics : PCCP·Shahar SukenikDaniel Harries
Nov 4, 2017·Physical Chemistry Chemical Physics : PCCP·Jian WangJiwen Feng
Nov 23, 2018·Biochimica Et Biophysica Acta. Biomembranes·N A KasianL N Lisetski
Feb 3, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Sangita KunduNilmoni Sarkar
Sep 10, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Giuseppe M PaternòGuglielmo Lanzani
Oct 12, 2018·Chemistry and Physics of Lipids·Grażyna NeunertKrzysztof Polewski
May 20, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Ravi Kumar Venkatraman, Carlos R Baiz
Mar 29, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·S Shankara Gayathri, Archita Patnaik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.