DNA-accelerated atom transfer radical polymerization on a gold surface

Langmuir : the ACS Journal of Surfaces and Colloids
Xinhui Lou, Lin He

Abstract

A significantly increased polymer growth rate was observed during a surface-initiated ATRP reaction in the presence of DNA molecules. To investigate this phenomenon, thiolated single-stranded DNA molecules (ssDNAs) with ATRP initiators coupled at the distal point were used as the model molecule in the study. In comparison, a small molecule, HS-(CH(2))(11)NHCOC(CH(3))(2)Br, was used to provide a less-polar surface coating for polymer grafting. 2-Hydroxyethyl methacrylate (HEMA) and monomethoxy-capped oligo(ethylene glycol) methacrylate (OEGMA) were used as the ATRP monomers. The polymer growth rates were monitored by measuring the thickness of the polymer films formed at different times. Our results show that the presence of DNA molecules, although at a less-than-1% surface coverage, significantly accelerated the growth rates of both poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(oligoethylene glycol methacrylate) (POEGMA) at the beginning of the ATRP reactions. This accelerating effect was suspected to be a combined result of the highly charged sugar-phosphate backbones of DNA molecules and the formation of Cu complexes with DNA bases. After the initial polymer growth, a smaller yet constant polymer growth rate was observed...Continue Reading

References

Jan 1, 1995·Bioconjugate Chemistry·N Nakajima, Y Ikada
Dec 26, 2001·Chemical Reviews·K Matyjaszewski, J Xia
Jun 20, 1996·Chemical Reviews·Abraham Ulman
Apr 24, 2003·Journal of the American Chemical Society·Dmitri Y PetrovykhMichael J Tarlov
May 5, 2005·Journal of the American Chemical Society·Debora Bontempo, Heather D Maynard
Jul 1, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Selim ElhadjRavi F Saraf

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Citations

Dec 18, 2008·Analytical and Bioanalytical Chemistry·Weiming Zheng, Lin He
Jul 12, 2012·Accounts of Chemical Research·Yafeng WuSongqin Liu
Aug 31, 2007·Biosensors & Bioelectronics·Geoffrey O Okelo, Lin He
Feb 22, 2011·Biotechnology and Bioengineering·Brad J BerronChristopher N Bowman
Jan 13, 2011·Chemistry : a European Journal·Liang YuanSongqin Liu
Feb 1, 2014·Angewandte Chemie·Saadyah E AverickSubha R Das
Feb 19, 2009·Lab on a Chip·Hadley D SikesChristopher N Bowman
Aug 31, 2020·Progress in Polymer Science·Marco S MessinaHeather D Maynard
Mar 20, 2021·Chemical Reviews·Colette J WhitfieldTanja Weil
Jul 9, 2009·Analytical Chemistry·Yafeng WuLin He
Nov 9, 2018·Biomacromolecules·Thorsten LueckerathTanja Weil

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