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DNA accessibility of chromatosomes quantified by automated image analysis of AFM data

Scientific Reports

Sep 4, 2019

Martin WürtzKarl Rohr

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Abstract

DNA compaction and accessibility in eukaryotes are governed by nucleosomes and orchestrated through interactions between DNA and DNA-binding proteins. Using QuantAFM, a method for automated image analysis of atomic force microscopy (AFM) data, we performed a detailed statistical analysi...read more

Mentioned in this Paper

Diagnostic Imaging
DNA
DNA-Binding Proteins
Histone H1
Histones
DNA Sequence
Evaluation
Microscopy, Atomic Force
AFM protein, human
Asymmetry
6
8
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DNA accessibility of chromatosomes quantified by automated image analysis of AFM data

Scientific Reports

Sep 4, 2019

Martin WürtzKarl Rohr

PMID: 31484969

DOI: 10.1038/s41598-019-49163-4

Abstract

DNA compaction and accessibility in eukaryotes are governed by nucleosomes and orchestrated through interactions between DNA and DNA-binding proteins. Using QuantAFM, a method for automated image analysis of atomic force microscopy (AFM) data, we performed a detailed statistical analysi...read more

Mentioned in this Paper

Diagnostic Imaging
DNA
DNA-Binding Proteins
Histone H1
Histones
6
8

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Paper Details
References
  • References57
  • Citations
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  • References57
  • Citations
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