DNA affinity to biological membranes is enhanced due to complexation with hydrophobized polycation

FEBS Letters
A A YaroslavovV A Kabanov

Abstract

The interaction of negatively charged liquid phosphatidylcholine/cardiolipin liposomes with water-soluble negatively charged DNA/cetylpyridinium bromide and DNA/poly(N-alkyl-4-vinylpyridinium bromide) complexes was studied. It is shown that the DNA/cetylpyridinium bromide complex while interacting with the liposomes is destroyed, so that the cetylpyridinium cation is incorporated into the liposomal membrane and DNA remains in the solution. The DNA/poly-(N-ethyl-4-vinylpyridinium bromide) complex does not interact at all with the liposomes. On the contrary, the complex of DNA with the poly(vinylpyridinium) cation carrying a small amount of N-cetyl groups is adsorbed on the membrane as a whole. The data obtained indicate that complexation of DNA with hydrophobized polycations can be used for enhancing DNA affinity to biological membranes.

References

Mar 23, 1990·Science·J A WolffP L Felgner
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J P BehrJ Perez-Mutul
Mar 1, 1988·Somatic Cell and Molecular Genetics·R J AubinM C Paterson
Sep 30, 1987·Biochemical and Biophysical Research Communications·C Y Wang, L Huang
Aug 1, 1987·Molecular and Cellular Biology·C Chen, H Okayama
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·H PotterP Leder

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Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·V A Kabanov, A V Kabanov
Jun 6, 2000·Advanced Drug Delivery Reviews·A P Rolland, R J Mumper
Jan 18, 2013·Therapeutic Delivery·Milagros Avila-OliasIrene Canton
Oct 10, 2013·Macromolecular Bioscience·Sung Duk JoYoon Sung Nam
Jan 16, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Sergey K FilippovPetr Stepánek

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