DNA at aqueous/solid interfaces: chirality-based detection via second harmonic generation activity

Journal of the American Chemical Society
Faith C BomanFranz M Geiger

Abstract

We present electronic spectra of single-strand and duplex DNA oligonucleotides covalently attached to fused quartz/aqueous interfaces and demonstrate that a strong nonlinear optical linear dichroism response is obtained when adenine and thymine bases undergo Watson-Crick base pairing to form a double helix. Complementary chi(3) charge screening studies indicate that the signal originates from 5 x 10(11) strands per square centimeter, or 6 attomoles of surface-bound oligonucleotides. The label-free, molecular-specific nature afforded by nonlinear optical studies of DNA at aqueous/solid interfaces allows for the real-time tracking of interfacial DNA hybridization for the first time.

References

Aug 15, 1996·Nature·A P AlivisatosP G Schultz
Aug 1, 1996·Nucleic Acids Research·L A ChriseyC E O'Ferrall
Sep 8, 2000·Science·T A TatonR L Letsinger
Feb 19, 2002·Chemical Reviews·Gordon E. BrownJohn M. Zachara
May 15, 2002·Physical Review Letters·Laura J KaufmanGraham R Fleming
Jan 24, 2003·Nature·Nadrian C Seeman
Feb 6, 2003·Journal of the American Chemical Society·Rongchao JinGeorge C Schatz
Jun 13, 2003·Ultramicroscopy·Eric FinotAlain Dereux
Jul 18, 2003·Nature·William H Steel, Robert A Walker
May 4, 2004·Optics Letters·T BrixnerG R Fleming
Jun 24, 2004·Journal of the American Chemical Society·Nurettin DemirdövenAndrei Tokmakoff
Aug 18, 2004·Science·Punit KohliCharles R Martin
Sep 10, 2004·Journal of the American Chemical Society·Hind A Al-AbadlehFranz M Geiger
Oct 27, 2004·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Garth J Simpson
Dec 1, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Selina MosesStefan Franzen
Nov 3, 2005·Journal of the American Chemical Society·Faith C BomanFranz M Geiger
Nov 10, 2005·Journal of the American Chemical Society·Christopher T KonekFranz M Geiger
Dec 27, 2005·The Journal of Physical Chemistry. B·Amanda L MifflinFranz M Geiger
Apr 13, 2006·Chemical Reviews·Sandhya GopalakrishnanMary Jane Shultz
Sep 30, 2006·Science·John A McGuire, Y Ron Shen
Nov 10, 2006·The Journal of Physical Chemistry. B·Amanda L MifflinFranz M Geiger
May 25, 2007·Journal of the American Chemical Society·Grace Y StokesFranz M Geiger
Jun 8, 2007·The Journal of Physical Chemistry. a·Joshua C VaughanKeith A Nelson
Jun 21, 2007·Journal of the American Chemical Society·George W H WurpelMischa Bonn
Jan 26, 2008·Journal of the American Chemical Society·Igor V StiopkinAlexander V Benderskii
Feb 1, 2008·Nature·Sung Yong ParkChad A Mirkin
Oct 4, 2008·Journal of the American Chemical Society·Ronald D WamplerGarth J Simpson
Nov 14, 2008·Journal of the American Chemical Society·Julianne M Gibbs-DavisFranz M Geiger
Nov 1, 1984·Optics Letters·G Yang, Y R Shen

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Citations

Jan 12, 2013·ACS Nano·J Jussi ToppariWolfgang Fritzsche
Nov 25, 2011·Proceedings of the National Academy of Sciences of the United States of America·Benjamin DoughtyKenneth B Eisenthal
Apr 25, 2015·Physical Chemistry Chemical Physics : PCCP·Zhiguo LiJulianne M Gibbs-Davis
May 12, 2018·Journal of Colloid and Interface Science·Mohammad Abu-LabanDaniel J Hayes
Dec 25, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Yanli TangDavid G Whitten
May 22, 2010·Journal of the American Chemical Society·R Kramer CampenMischa Bonn
Dec 13, 2012·The Journal of Physical Chemistry. B·Joseph G Holland, Franz M Geiger
Jul 4, 2013·The Journal of Physical Chemistry. a·Carlena J EbbenFranz M Geiger

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