DNA based arithmetic function: a half adder based on DNA strand displacement

Nanoscale
Wei LiYan Liu

Abstract

Biomolecular programming utilizes the reactions and information stored in biological molecules, such as proteins and nucleic acids, for computational purposes. DNA has proven itself an excellent candidate for building logic operating systems due to its highly predictable molecular behavior. In this work we designed and realized an XOR logic gate and an AND logic gate based on DNA strand displacement reactions. These logic gates utilize ssDNA as input and output signals. The XOR gate and the AND gate were used as building blocks for constructing a half adder logic circuit, which is a primary step in constructing a full adder, a basic arithmetic unit in computing. This work provides the field of DNA molecular programming with a potential universal arithmetic tool.

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Mar 30, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Bernadine O F McKinneyA Prasanna de Silva
Nov 23, 2017·Nanoscale·Linqiang PanCheng Zhang
Oct 18, 2018·Chemistry : a European Journal·Shu YangQianfan Yang
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Sep 12, 2020·Computational and Structural Biotechnology Journal·Xiaokang ZhangShihua Zhou
Apr 21, 2021·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Shuang ZhaoMing Chen
Apr 20, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Hui LvFei Wang
Jul 20, 2018·ACS Omega·Chengye ZouYuan Liu
Apr 18, 2017·ACS Synthetic Biology·Masayuki OharaRyuji Kawano
Aug 29, 2021·ACS Applied Materials & Interfaces·Liping ZhuXiurong Yang
Oct 5, 2021·Chemical Society Reviews·Lanlan ChenHuanghao Yang

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