DNA-Based Multiconstituent Dynamic Networks: Hierarchical Adaptive Control over the Composition and Cooperative Catalytic Functions of the Systems

Journal of the American Chemical Society
Zhixin ZhouItamar Willner

Abstract

The information encoded in the base sequences of nucleic acids is used to construct [3 × 2] or [3 × 3] constitutional dynamic networks (CDNs) composed of six or nine constituents, respectively. In the presence of appropriate triggers, the adaptive and hierarchical reconfiguration of the CDNs is demonstrated. The reconfiguration of the CDNs, which involves the triggered stabilization and upregulation of a specific constituent is accompanied by the upregulation of the constituents that do not share component connectivities with the trigger-stabilized constituent, and by the concomitant downregulation of the constituents sharing component connectivities with the trigger-stabilized constituent. Using a set of different triggers, a series of reconfigured networks-in-networks are demonstrated. The operation and reconfiguration of the CDNs are based on the following motives: (i) Each of the constituents in the [3 × 2] or [3 × 3] CDNs is composed of a supramolecular structure consisting of two duplex-bridged double-loop quasi-circle units. The hybridization of a single-stranded trigger with the double-loop domain stabilizes the respective constituent, and this results in the reconfiguration of the CDNs. (ii) To each of the constituents...Continue Reading

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Citations

Nov 11, 2019·Emerging Topics in Life Sciences·Verena Wulf, Itamar Willner
Jan 12, 2021·Journal of Colloid and Interface Science·Paulo F A CostaAdriana P Gerola
Feb 25, 2021·Proceedings of the National Academy of Sciences of the United States of America·Anil Kumar BandelaGonen Ashkenasy
May 13, 2021·Chemical Communications : Chem Comm·Yu-Peng ZhangDai-Wen Pang
Jul 15, 2021·Advanced Science·Shasha LuXiurong Yang
Nov 13, 2019·Journal of the American Chemical Society·Meixia He, Jean-Marie Lehn
Dec 17, 2020·Journal of the American Chemical Society·Liang YueItamar Willner
Apr 7, 2020·Analytical Chemistry·Xue-Nan FengDe-Ming Kong
Dec 9, 2020·Journal of the American Chemical Society·Sivan LilienthalItamar Willner
Dec 24, 2020·Journal of the American Chemical Society·Zhixin ZhouItamar Willner
Dec 7, 2018·Analytical Chemistry·Simona RanalloFrancesco Ricci
Aug 14, 2020·Journal of the American Chemical Society·Liang YueItamar Willner
Sep 22, 2020·Journal of the American Chemical Society·Shan WangItamar Willner
Dec 3, 2021·Chemistry : a European Journal·Chen WangItamar Willner
Jan 6, 2022·Chemical Society Reviews·Chen WangItamar Willner

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