DNA-Biofunctionalization of CTAC-Capped Gold Nanocubes

Nanomaterials
Nicole SlesionaWolfgang Fritzsche

Abstract

Clinical diagnostics and disease control are fields that strongly depend on technologies for rapid, sensitive, and selective detection of biological or chemical analytes. Nanoparticles have become an integral part in various biomedical detection devices and nanotherapeutics. An increasing focus is laid on gold nanoparticles as they express less cytotoxicity, high stability, and hold unique optical properties with the ability of signal transduction of biological recognition events with enhanced analytical performance. Strong electromagnetic field enhancements can be found in close proximity to the nanoparticle that can be exploited to enhance signals for e.g., metal-enhanced fluorescence or Raman spectroscopy. Even stronger field enhancements can be achieved with sharp-edged nanoparticles, which are synthesized with the help of facet blocking agents, such as cetyltrimethylammonium bromide/chloride (CTAB/CTAC). However, chemical modification of the nanoparticle surface is necessary to reduce the particle's cytotoxicity, stabilize it against aggregation, and to bioconjugate it with biomolecules to increase its biocompatibility and/or specificity for analytical applications. Here, a reliable two-step protocol following a ligand exc...Continue Reading

References

Aug 15, 1996·Nature·A P AlivisatosP G Schultz
Apr 14, 2005·Chemical Reviews·J Christopher LoveGeorge M Whitesides
Jul 1, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Selim ElhadjRavi F Saraf
Jul 1, 2006·Analytical Chemistry·Andreas B DahlinFredrik Höök
Dec 15, 2006·Analytical Chemistry·Sarah J HurstChad A Mirkin
Jan 24, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Jeffrey M McMahon, Steven R Emory
Jul 20, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Chenxu YuJoseph Irudayaraj
Jun 12, 2009·Small·Kyle J M BishopBartosz A Grzybowski
Sep 30, 2009·Chemical Communications : Chem Comm·Denis GentiliMauro Comes Franchini
Nov 24, 2011·Nano Reviews·Panikkanvalappil R SajanlalThalappil Pradeep
May 2, 2013·Bioconjugate Chemistry·Pratixa P JoshiKonstantin V Sokolov
May 17, 2014·Journal of the American Chemical Society·Matthew N O'BrienChad A Mirkin
Nov 5, 2014·The Analyst·Ming LiNianqiang Wu
Jun 24, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Jiuxing LiChaoyong James Yang
Jun 14, 1999·Angewandte Chemie·Colin J LowethPeter G Schultz
May 17, 2018·Medicinal Research Reviews·Florence MasseElodie Boisselier
Mar 29, 2019·Chemical Reviews·Amelie Heuer-JungemannAntonios G Kanaras
Jun 18, 2019·ChemistryOpen·Piotr SzustakiewiczWiktor Lewandowski

❮ Previous
Next ❯

Citations

May 11, 2021·Frontiers in Chemistry·Yingbo LiXilin Sun

❮ Previous
Next ❯

Methods Mentioned

BETA
biosensors
biosensor
biosensing
surface plasmon resonance
BSPP

Software Mentioned

Python
Zetasizer

Related Concepts

Related Feeds

AFM in situ DNA

AFM in situ DNA describes in situ analysis (or study) of DNA using atomic force microscopy. Discover the latest research on AFM in situ DNA here.