PMID: 9541640Apr 29, 1998Paper

DNA breakage by L-DOPA and Cu(II): breakage by melanin and bacteriophage inactivation

Mutation Research
S Husain, S M Hadi

Abstract

We have previously shown that L-DOPA in the presence of Cu(II) caused DNA cleavage through the generation of reactive oxygen species such as the hydroxyl radical. Since L-DOPA is the precursor for the synthesis of melanin, we have studied the action of melanin on DNA in a similar reaction. In this paper, we show that melanin in the presence of Cu(II) also causes DNA strand breakage. However, the rate of such strand breakage is considerably less than l-DOPA. Melanin and L-DOPA are both capable of generating superoxide anion. Furthermore, the action of L-DOPA and Cu(II) on bacteriophage lambda reduces its viability. The results are discussed in relation to the putative role of L-DOPA-Cu(II) system as a source of endogenous generation of reactive oxygen species.

References

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Citations

Dec 24, 2003·Teratogenesis, Carcinogenesis, and Mutagenesis·Ninoslav Djelic, Diana Anderson
Aug 6, 1999·Biochimica Et Biophysica Acta·S F AsadS M Hadi
Aug 17, 2010·Bioresource Technology·Jieni LianManuel Garcia-Perez
Sep 30, 2006·Chemistry : a European Journal·Alejandro González OriveRoberto C Salvarezza

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