DNA breakage drives nuclear search.

Nature Cell Biology
Grzegorz Ira, Philip J Hastings

Abstract

The search for a homologous template is a fundamental, yet largely uncharacterized, reaction in DNA double-strand break repair. Two reports now demonstrate that broken chromosomes increase their movement and explore large volumes of nuclear space searching for a homologous template. Break mobility requires resection and recombination enzymes, as well as damage-checkpoint components.

References

Jun 23, 2006·PLoS Genetics·Peter L Houston, James R Broach
Mar 30, 2010·Nature·Malgorzata BzymekNeil Hunter
Feb 10, 2012·Nature·Anthony L Forget, Stephen C Kowalczykowski
Apr 10, 2012·Nature Cell Biology·Judith Miné-Hattab, Rodney Rothstein

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Citations

Dec 18, 2013·Genome Biology·Ishita S MehtaBasuthkar J Rao
Nov 26, 2013·Molecular Cell·Jolien Suzanne VerdaasdonkKerry Bloom
Oct 6, 2016·Mechanisms of Ageing and Development·Kalliopi StratigiGeorge A Garinis
Jun 13, 2015·The Journal of Biological Chemistry·Danielle S KrasnerHengyao Niu

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