Abstract
A wide variety of approaches, all using gene transfer, have been tested experimentally as alternative means to vaccinate against cancer, either prophylactically or therapeutically. These include both ex vivo and in vivo gene transfer to tumour and/or non-tumour cells, using both viral and non-viral vectors. The transferred DNA has varied widely as well, including genomic or cDNA encoding tumour-associated or oncofoetal antigens, cytokines, histocompatibility molecules, and costimulatory molecules. Several of these approaches have been applied in human clinical trials. This review summarizes those approaches, then compares and evaluates various methods using cytokine DNA in conjunction with autologous tumour cells, with particular emphasis on particle-mediated gene transfer via a gene gun. Finally, prospects and needs for further development are discussed.
References
Dec 24, 1992·Cell·L ChenP S Linsley
Jun 11, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A ThompsonA Fefer
Aug 1, 1990·Molecular and Cellular Biology·D G MillerA D Miller
Feb 1, 1990·Cancer·E C Borden, P M Sondel
Aug 1, 1989·Journal of Immunogenetics·S Ostrand-RosenbergG A Cole
Mar 2, 1988·Journal of the National Cancer Institute·J A SosmanP M Sondel
May 1, 1995·Nature Medicine·N S Yang, W H Sun
Jan 15, 1993·Science·S E Townsend, J P Allison
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·W H SunN S Yang
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·W SchmidtM L Birnstiel
Mar 1, 1995·Human Gene Therapy·A J BernsF F Marshall
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G DranoffR C Mulligan
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G J NabelA E Chang
Dec 1, 1995·Human Gene Therapy·H TaharaL Zitvogel
Oct 1, 1996·Nature Medicine·D DillooM Brenner
Aug 20, 1996·Human Gene Therapy·D M MahviN S Yang
Nov 20, 1996·Journal of the National Cancer Institute·S A Rosenberg
Nov 1, 1996·Molecular Medicine Today·N S YangD McCabe
Jan 1, 1997·Journal of the National Cancer Institute·J A Roth, R J Cristiano
May 1, 1997·Human Gene Therapy·D M MahviR Logrono
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·T D ArmstrongS Ostrand-Rosenberg
Citations
Sep 3, 2002·Journal of Biotechnology·Kevin R Smith
Sep 6, 2003·Archives of Medical Research·Kevin R Smith
Mar 30, 2000·Vaccine·M KwissaR Schirmbeck
Oct 16, 2002·Brain Research. Brain Research Protocols·John O'Brien, Sarah C R Lummis
Jun 28, 2003·Viral Immunology·Chiyoko NukuzumaEiji Konishi
Oct 30, 1998·Human Gene Therapy·Z Q YeN S Yang
Apr 17, 2003·The Journal of Clinical Investigation·Claudia CurcioGuido Forni
Jun 19, 2001·Biological Chemistry·R Schirmbeck, J Reimann
Dec 5, 2012·Advanced Biomedical Research·Nouri NayerossadatPalizban Abas Ali
Jul 5, 2005·Expert Opinion on Investigational Drugs·M D Street, R W Tindle
Dec 4, 2003·Expert Opinion on Biological Therapy·Catherine J AckleyChristopher H Lowrey
May 18, 2010·Immunobiology·Galia RamírezArturo Ferreira
Feb 13, 2001·Experimental Neurology·G Zhang, M E Selzer
May 20, 1999·Acta Microbiologica Et Immunologica Hungarica·J C HorvathE Horvath
Jul 24, 2001·Anesthesiology·C L WuJ Yang
Aug 2, 2000·Gene Therapy·S KuriyamaH Fukui
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M BiondoF Alderuccio
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antonio RosatoPaola Zanovello