DNA content analysis of colorectal serrated lesions detects an aneuploid subset of inflammatory bowel disease-associated serrated epithelial change and traditional serrated adenomas

Histopathology
Won-Tak ChoiRyan M Gill

Abstract

Serrated lesions (SLs), including sessile serrated adenoma (SSA) and traditional serrated adenoma (TSA), are important premalignant lesions for colorectal cancer (CRC). Although a small subset of SLs are known to harbour TP53 mutations and Wnt/β-catenin pathway activation, suggesting that they may develop dysplasia or CRC via a 'chromosomal instability (CIN)-like' pathway, it is unclear if aneuploidy (characteristic of conventional adenoma) ever develops in SLs and is associated with development of dysplasia or CRC, in this context. DNA flow cytometry was performed on 31 inflammatory bowel disease (IBD)-associated SLs without dysplasia [including 10 non-targeted 'serrated epithelial change' (SEC), 14 SSAs and seven hyperplastic polyps (HPs)] as well as 48 dysplastic SSAs and TSAs. One (10%) of 10 SEC cases demonstrated aneuploidy and subsequently developed high-grade dysplasia (HGD) within 4 months, whereas the remaining SEC cases showed normal DNA content without evidence of dysplasia or CRC on follow-up. One (3.3%) of 30 TSAs without HGD and two (66.7%) of three TSAs with HGD also showed aneuploidy, but no patient developed CRC. By contrast, all SSAs (with or without dysplasia) and HPs showed normal DNA content, but four SSA ...Continue Reading

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Citations

Dec 12, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Won-Tak ChoiGregory Y Lauwers
Apr 8, 2020·Future Science OA·Nicholas S SamelHiroshi Mashimo
Oct 9, 2020·International Journal of Surgical Pathology·Iva BrcicKarl Kashofer
Aug 5, 2020·Postgraduate Medicine·Kenneth P BattsRobert P McCabe

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