DNA damage: a sensible mediator of the differentiation decision in hematopoietic stem cells and in leukemia

International Journal of Molecular Sciences
Cary N Weiss, Keisuke Ito

Abstract

In the adult, the source of functionally diverse, mature blood cells are hematopoietic stem cells, a rare population of quiescent cells that reside in the bone marrow niche. Like stem cells in other tissues, hematopoietic stem cells are defined by their ability to self-renew, in order to maintain the stem cell population for the lifetime of the organism, and to differentiate, in order to give rise to the multiple lineages of the hematopoietic system. In recent years, increasing evidence has suggested a role for the accumulation of reactive oxygen species and DNA damage in the decision for hematopoietic stem cells to exit quiescence and to differentiate. In this review, we will examine recent work supporting the idea that detection of cell stressors, such as oxidative and genetic damage, is an important mediator of cell fate decisions in hematopoietic stem cells. We will explore the benefits of such a system in avoiding the development and progression of malignancies, and in avoiding tissue exhaustion and failure. Additionally, we will discuss new work that examines the accumulation of DNA damage and replication stress in aging hematopoietic stem cells and causes us to rethink ideas of genoprotection in the bone marrow niche.

References

Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M S Wold, T Kelly
Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
Aug 30, 1984·Biochemical and Biophysical Research Communications·O Ostling, K J Johanson
Jun 13, 1998·The Journal of Biological Chemistry·M MalangaF R Althaus
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·S H CheshierI L Weissman
Mar 25, 1999·Genes & Development·L ChenN C Walworth
Sep 9, 1999·The Journal of Cell Biology·E P RogakouW M Bonner
Mar 29, 2000·The Journal of Biological Chemistry·E P RogakouW M Bonner
Apr 27, 2000·FEBS Letters·N TakaoK Yamamoto
Mar 10, 2001·Molecular and Cellular Biology·L AndersonY Adachi
Mar 30, 2001·The Journal of Biological Chemistry·G WardC G Dosoretz
Sep 26, 2001·The Journal of Biological Chemistry·S BurmaD J Chen
Nov 1, 2001·Annual Review of Cell and Developmental Biology·I L WeissmanF Gage
Sep 20, 2002·Nature·Geert J P L KopsBoudewijn M T Burgering
Nov 26, 2002·Nature Cell Biology·Oscar Fernandez-CapetilloAndré Nussenzweig
Jan 31, 2003·Nature·Christopher J Bakkenist, Michael B Kastan
Jun 7, 2003·Science·Lee Zou, Stephen J Elledge
Jan 16, 2004·The Journal of Biological Chemistry·Ryan D BomgardenKarlene A Cimprich
Jan 20, 2004·Molecular and Cellular Biology·Keziban Unsal-Kaçmaz, Aziz Sancar
Aug 13, 2004·The New England Journal of Medicine·Catriona H M JamiesonIrving L Weissman
Mar 1, 2005·Cell·Robert S BalabanToren Finkel
Apr 23, 2005·Cell Cycle·Jirina BartkovaJiri Bartek
Dec 7, 2005·The Journal of Experimental Medicine·Emmanuelle PasseguéIrving L Weissman
Mar 28, 2006·Cell·Michael F Clarke, Margaret Fuller

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Citations

Jun 23, 2016·Radiation Research·Kalpana MujooTej K Pandita
Sep 16, 2017·Nucleus·Olga ShubernetskayaIgor Kireev
Sep 21, 2018·Leukemia & Lymphoma·Giovanni D'ArenaVitalba Ruggieri
Nov 16, 2017·Oncotarget·Limei WuWei Du
Apr 17, 2016·International Journal of Hematology·Sha HaoTao Cheng
Jul 15, 2017·International Journal of Hematology·Domenico Delia, Shuki Mizutani

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Methods Mentioned

BETA
genoprotection
electrophoresis

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