May 16, 2020

DNA Damage, an Innocent Bystander in Atrial Fibrillation and Other Cardiovascular Diseases?

Frontiers in Cardiovascular Medicine
Kennedy S Ramos, Bianca J J M Brundel

Abstract

Atrial Fibrillation (AF) is the most common clinical tachyarrhythmia with a strong tendency to progress in time. AF is difficult to treat and therefore there is a great need to dissect root causes of AF with the ultimate goal to develop mechanism-based (drug) therapies. New findings related to mechanisms driving AF progression indicate a prime role for DNA damage-induced metabolic remodeling. A recent study uncovered that AF results in oxidative DNA damage and consequently excessive poly-ADP-ribose polymerase 1 (PARP1) activation and nicotinamide adenine dinucleotide (NAD+) depletion and finally atrial cardiomyocyte electrical and contractile dysfunction. This newly elucidated role of DNA damage in AF opens opportunities for novel therapeutic strategies. Recently developed PARP inhibitors, such as ABT-888 and olaparib, provide beneficial effects in limiting experimental AF, and are also found to limit atherosclerotic coronary artery disease and heart failure. Another therapeutic option to protect against AF is to replenish the NAD+ pool by supplementation with NAD+ or its precursors, such as nicotinamide and nicotinamide riboside. In this review, we describe the role of DNA damage-mediated metabolic remodeling in AF and other c...Continue Reading

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Mentioned in this Paper

Cerebrovascular Accident
Coronary Atherosclerosis of Native Coronary Artery
Pharmacologic Substance
DNA Damage
Poly(ADP-ribose) Polymerase Inhibitors
Nicotinamide adenine dinucleotide (NAD)
Myocytes, Cardiac
Olaparib
Tachycardia, Ventricular
Clinical Trials

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