Jul 24, 2003

DNA damage and stress transcripts in Saccharomyces cerevisiae mutant sgs1

Mechanisms of Ageing and Development
Rebecca C FryChoKyun Rha

Abstract

The human aging diseases Werner and Bloom syndromes are a result of mutation of the WRN and BLM genes, respectively. The SGS1 gene of Saccharomyces cerevisiae is homologous to the human WRN and BLM genes of the RecQ DNA helicase family. Deletion of SGS1 results in accelerated yeast aging and a reduction in life span as well as cell cycle arrest. We demonstrate that SGS1 deletion, DNA damage, and stress show similar transcriptional responses in yeast. Our comparative analysis of the genome-wide expression response of SGS1 deletion, stress and DNA damage indicates parallel transcriptional responses to cellular insult and aging in yeast.

Mentioned in this Paper

Saccharomyces cerevisiae Proteins
Bloom Syndrome
Saccharomyces cerevisiae allergenic extract
Werner Syndrome
Transcription, Genetic
RecQ Helicases
Gene Deletion Abnormality
Gene Deletion
Gene Expression Regulation, Fungal
Senility

About this Paper

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