PMID: 9552393Jan 1, 1996Paper

DNA damage checkpoints: implications for cancer therapy

Progress in Cell Cycle Research
P M O'Connor, S Fan

Abstract

DNA damage evokes a complex array of cellular responses, including cycle arrest in late G1 and/or G2 phases, and delayed progression through S phase. Arrest at these points in the cell cycle is governed, in large part, by a series of control systems, commonly termed "checkpoints". Activation of these checkpoints tends to protect cells from DNA damage by providing cells additional time to complete DNA repair. We discuss the impact of these DNA damage checkpoints on the chemosensitivity of human cancer cells. We focus on some of the complexities of the p53-dependent G1 checkpoint and review some recently discovered vulnerabilities in p53 disrupted cells that might be pharmacologically exploited for cancer treatment.

Citations

Apr 2, 1999·Nucleic Acids Research·V M MarathiasP H Bolton
Apr 5, 2000·The Journal of Biological Chemistry·S JinQ Zhan
Sep 7, 2000·The Journal of Biological Chemistry·Q YangX W Wang
Jul 5, 2003·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·J ZhouY Tang
Aug 1, 2007·Physical Biology·Roberto ChignolaEdoardo Milotti
May 9, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hiroshi ShigetomiHiroshi Kobayashi
Nov 29, 2005·Molecular and Cellular Biochemistry·Rama S RangaDamodaran Chendil
Nov 19, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yasumasa OhyagiTakeshi Tabira
Aug 28, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·V CeperoA Carnero
Aug 28, 2010·European Journal of Pharmacology·Ajanta ChakrabortyPartha Roy
Mar 11, 1999·Current Opinion in Genetics & Development·M D Garrett, A Fattaey
Oct 2, 2001·Pharmacology & Therapeutics·M LeszczynieckaP B Fisher
Oct 29, 2010·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Seema GuptaMansoor M Ahmed
Jan 10, 2012·Biochemical Pharmacology·Michelle Martinez-Rivera, Zahid H Siddik

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Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

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