PMID: 1202330Dec 1, 1975Paper

DNA damage, DNA repair and chromosome aberrations of xeroderma pigmentosum cells and controls following exposure to nitrosation products of methylguanidine

Mutation Research
L W Lo, H F Stich

Abstract

Nitrosation of methylguanidine (MG) led to products that caused DNA fragmentation (shift in sedimentation profiles of velocity centrifugation through alkaline sucrose gradients), a DNA repair synthesis (unscheduled uptake of (3H]TdR), chromosome aberrations and a lethal effect of cultured human fibroblasts. The response of repair-deficient xeroderma pigmentosum cells did not differ from that of controls. The nitrosation of MG must be carried out at a pH level below 3, in order to obtain products that react with cellular DNA. The results show that a DNA repair synthesis of human fibroblasts appears to be a sensitive assay for carcinogenic and mutagenic nitrosation products which may be formed within an organism from non-carcinogenic compounds.

References

Mar 8, 1972·Nature: New Biology·M GreenblattW Lijinsky
Jan 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·H F Stich, R H San
Apr 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·H F StichR H San
Mar 15, 1971·International Journal of Cancer. Journal International Du Cancer·R Montesano, P N Magee
Jul 1, 1969·Food and Cosmetics Toxicology·N P SenL Schwinghamer

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Citations

Feb 1, 1978·Environmental Health Perspectives·H F StichJ Koropatnick
Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·R H San, H F Stich

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