DNA damage foci: Meaning and significance

Environmental and Molecular Mutagenesis
Kai RothkammSusanne Burdak-Rothkamm

Abstract

The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci, has revolutionized the detection of these lesions and has enabled studies of the cellular machinery that contributes to their repair. Double-strand breaks are induced directly by a number of physical and chemical agents, including ionizing radiation and radiomimetic drugs, but can also arise as secondary lesions during replication and DNA repair following exposure to a wide range of genotoxins. Here we aim to review the biological meaning and significance of DNA damage foci, looking specifically at a range of different settings in which such markers of DNA damage and repair are being studied and interpreted.

References

Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·T Tsuzuki MoritaT
Sep 9, 1999·The Journal of Cell Biology·E P RogakouW M Bonner
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·H ZhouT K Hei
Sep 19, 2002·Radiation Research·Olga A SedelnikovaWilliam M Bonner
Apr 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kai Rothkamm, Markus Löbrich
Apr 17, 2003·The Journal of Biological Chemistry·Irene M WardJunjie Chen
Jun 7, 2003·Nature Cell Biology·Arkady CelesteAndré Nussenzweig
Aug 5, 2003·Molecular and Cellular Biology·Kai RothkammMarkus Löbrich
Jan 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Peggy L Olive, Judit P Banáth
Feb 3, 2004·Nature Cell Biology·Olga A SedelnikovaJ Carl Barrett
Apr 2, 2004·Nature Reviews. Cancer·Ashok R Venkitaraman
Sep 29, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Olov Fredrik QvarnströmIngela Turesson
Apr 15, 2005·Nature·Vassilis G GorgoulisThanos D Halazonetis
Jun 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Markus LöbrichMichael Uder
Apr 19, 2006·The Journal of Cell Biology·Simon Bekker-JensenJiri Lukas
Jun 24, 2006·Methods in Enzymology·Asako NakamuraWilliam M Bonner
Nov 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jörg BewersdorfKendall L Knight
Jul 12, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Toshiki TanakaZbigniew Darzynkiewicz
Oct 2, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peggy L OliveMira Keyes
Sep 2, 2008·Cancer Research·Susanne Burdak-RothkammKevin M Prise
Sep 6, 2008·Nucleic Acids Research·Andrea KinnerGeorge Iliakis
Sep 19, 2008·Environmental and Molecular Mutagenesis·Ori StaszewskiBernd Kaina
Apr 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ali SakMartin Stuschke
Apr 22, 2009·Methods in Molecular Biology·Toshiki TanakaZbigniew Darzynkiewicz
Jun 3, 2009·Mutation Research·Tatsushi Toyooka, Yuko Ibuki
Jul 25, 2009·Mutation Research·Gary Peter WattersCaroline Ann Austin

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Citations

Aug 2, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Chad M ThompsonMark A Harris
Apr 17, 2016·Nucleic Acids Research·Gouri ChatterjeeRyan B Jensen
Apr 26, 2016·Mechanisms of Ageing and Development·Eleonora CrocoAntonello Lorenzini
Jun 1, 2016·Frontiers in Genetics·Jing HuangMichael M Seidman
Aug 24, 2016·European Heart Journal Cardiovascular Imaging·M A HillW G McKenna
Aug 31, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Eleonora CrocoAntonello Lorenzini
Sep 3, 2016·Molecular Cell·Ryan R White, Jan Vijg
Nov 11, 2015·Life Sciences in Space Research·Christine E HellwegGünther Reitz
Oct 27, 2016·Nuklearmedizin. Nuclear Medicine·Roswitha RungeJörg Kotzerke
Apr 28, 2016·International Journal of Radiation Biology·Ute MauckschJörg Kotzerke
Oct 28, 2016·Cancer Biology & Therapy·Quhuan LiZhong Yun
Feb 6, 2017·The Plant Journal : for Cell and Molecular Biology·Takeshi HirakawaSachihiro Matsunaga
Apr 15, 2016·Scientific Reports·Dan HeHuijuan Liu
Dec 14, 2016·Histopathology·Lynette M ShollJason L Hornick
Jan 6, 2017·Radiation Research·Kenneth R FosterThomas F Budinger
Jun 7, 2017·Angewandte Chemie·Xiao-Qiang WangXian-Zheng Zhang
Jul 5, 2017·Nature Reviews. Urology·Mindy Kim Graham, Alan Meeker
Dec 3, 2017·Archives of Toxicology·Jan M F FischerAswin Mangerich
Nov 23, 2017·European Heart Journal·William R CritchleyChristopher A Miller
Oct 6, 2017·Antioxidants & Redox Signaling·Bryndon J Oleson, John A Corbett
Dec 19, 2017·Nucleic Acids Research·Michal Gavish-IzaksonYosef Shiloh
Sep 1, 2016·Development·Stephanie HilzAndrew Grimson
Sep 22, 2018·International Journal of Radiation Biology·Tyler A BeachJacob N Finkelstein
Oct 26, 2018·International Journal of Radiation Biology·S G R BarnardR A Quinlan
Nov 28, 2018·International Journal of Cancer. Journal International Du Cancer·Sabrina KöcherWael Yassin Mansour
Nov 9, 2018·Radiation Research·Michael N Cornforth, Bradford D Loucas
Apr 24, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Vanessa ValdiglesiasBlanca Laffon
Jan 25, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lianying FangQiang Liu
Jun 25, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chiao-Ling TsaiJason Chia-Hsien Cheng
Oct 26, 2018·International Journal of Radiation Biology·Tyler A BeachJacob N Finkelstein

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