PMID: 700888Aug 15, 1978Paper

DNA damage in liver, colon, stomach, lung and kidney of BALB/c mice treated with 1,2-dimethylhydrazine

International Journal of Cancer. Journal International Du Cancer
G BrambillaL Robbiano

Abstract

DNA single-strand breaks induced in various organs of BALB/c mice by treatment with a single dose of 1,2-dimethylhydrazine (DMH) were studied by means of the alkaline elution method modified in order to allow the evaluation of DNA damage in vivo with no need of radioactive prelabelling. DNA damage was detected in liver, lung, kidney, stomach and colon mucosa, with the liver showing the greatest amount of damage. Its degree was dependent on the dose and route of administration. A differential effect was evident in colon mucosa from Swiss and C57BL/6 mice which are respectively susceptible and resistant to the induction of bowel tumors by DMH. The higher degree of DNA damage found in liver in comparison with colon mucosa is consistent with the previously reported higher degree of DNA methylation, but does not correlate with the specificity of this carcinogen in inducing tumors of the large intestine in mice given repeated subcutaneous injections.

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Citations

May 1, 1991·Mutation Research·A MartelliG Brambilla
Mar 1, 1992·Toxicology in Vitro : an International Journal Published in Association with BIBRA·F MattioliG Brambilla
Feb 1, 1982·Journal of Toxicology and Environmental Health·G BrambillaS De Flora
May 10, 2000·Bioscience, Biotechnology, and Biochemistry·G WanN Kato
Aug 5, 2008·Toxicology and Applied Pharmacology·Michael Waters, Marcus Jackson
Mar 1, 1989·Toxicology and Applied Pharmacology·G BrambillaM Mazzei
Sep 1, 1980·Cancer Letters·M SchwarzG Eisenbrand
Mar 1, 1981·Pharmacological Research Communications·G BrambillaL Robbiano
Jun 19, 1998·Toxicology and Applied Pharmacology·A PapanikolaouD W Rosenberg
Jan 1, 1989·Environmental and Molecular Mutagenesis·A PinoP Grillo
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sandeep Kumar, Navneet Agnihotri

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