PMID: 25004448Jul 9, 2014Paper

DNA damage modulates interactions between microRNAs and the 26S proteasome

Oncotarget
Anna S TsimokhaNikolai A Barlev

Abstract

26S proteasomes are known as major non-lysosomal cellular machines for coordinated and specific destruction of ubiquitinylated proteins. The proteolytic activities of proteasomes are controlled by various post-translational modifications in response to environmental cues, including DNA damage. Besides proteolysis, proteasomes also associate with RNA hydrolysis and splicing. Here, we extend the functional diversity of proteasomes by showing that they also dynamically associate with microRNAs (miRNAs) both in the nucleus and cytoplasm of cells. Moreover, DNA damage induced by an anti-cancer drug, doxorubicin, alters the repertoire of proteasome-associated miRNAs, enriching the population of miRNAs that target cell cycle checkpoint regulators and DNA repair proteins. Collectively, these data uncover yet another potential mode of action for proteasomes in the cell via their dynamic association with microRNAs.

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Citations

Oct 21, 2015·Oncotarget·Katarzyna KlonowskaPiotr Kozlowski
Jul 20, 2016·Journal of Cellular Physiology·Anna S TsimokhaNikolai A Barlev
Jul 20, 2017·Clinical and Experimental Hypertension : CHE·Mo-Li ZhuPeng Li
Aug 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna S TsimokhaAlexey N Tomilin
Aug 6, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Bing LiangWenli Ma
Aug 22, 2015·Oncotarget·Tatyana A GrigorevaNickolai A Barlev
Dec 15, 2015·Cell Biochemistry and Function·Veronika GurianovaPeter Kruzliak
Oct 19, 2017·Cancer Metastasis Reviews·Yulin ChenXing Guo
Jun 1, 2018·Cell Biology International·Alexander ErmakovNickolai A Barlev
Mar 1, 2015·Molecular and Cellular Biochemistry·Veronika GurianovaVictor Dosenko
Oct 29, 2015·Current Opinion in Supportive and Palliative Care·Fábio S LiraJosé C Rosa Neto
Jul 15, 2015·Journal of Cell Science·Pawel LeznickiStephen High

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