DNA damage products (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines as potential biomarkers in human urine for atherosclerosis

Biochemistry
Pawel JarugaMiral Dizdaroglu

Abstract

We hypothesized that DNA damage products (5'R)-8,5'-cyclo-2'-deoxyadenosine (R-cdA) and (5'S)-8,5'-cyclo-2'-deoxyadenosine (S-cdA) may be well-suited biomarkers of risk and diagnosis for atherosclerosis. We tested this hypothesis by measuring the levels of R-cdA and S-cdA and another product, 8-hydroxy-2'-deoxyguanosine (8-OH-dG), in urine of atherosclerosis patients and healthy individuals using liquid chromatography-tandem mass spectrometry with isotope dilution. We showed the presence of these products at significantly greater concentrations in urine of atherosclerosis patients than in that of healthy individuals. Our data suggest that R-cdA and S-cdA can be accurately and reproducibly measured in human urine as potential biomarkers of risk and diagnosis for atherosclerosis.

References

Feb 11, 1995·Nucleic Acids Research·K MiaskiewiczA F Fuciarelli
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·J T ReardonA Sancar
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·I KuraokaT Lindahl
Dec 20, 2002·Nature·Peter Libby
Oct 3, 2003·Trends in Cardiovascular Medicine·Maria Grazia Andreassi, Nicoletta Botto
Oct 29, 2003·Hypertension·Yoshihiro Taniyama, Kathy K Griendling
Oct 29, 2003·Circulation·Kathy K Griendling, Garret A FitzGerald
May 12, 2004·Free Radical Biology & Medicine·Allan WeimannHenrik E Poulsen
Jun 11, 2004·Annual Review of Biochemistry·Aziz SancarStuart Linn
Mar 22, 2005·The International Journal of Biochemistry & Cell Biology·Rafal RozalskiRyszard Olinski
Nov 11, 2009·Journal of Clinical Biochemistry and Nutrition·Marcus S CookeMark D Evans
Dec 8, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·UNKNOWN European Standards Committee on Urinary (DNA) Lesion AnalysisMarcus S Cooke
Mar 11, 2010·Expert Review of Molecular Diagnostics·Sarah M WeakleyChangyi Chen
Jun 16, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Amanda E T ElsonSteven D Munger
Aug 14, 2010·Circulation Research·John R MercerMartin Bennett
Jul 6, 2011·Biochemical Pharmacology·Kelly Gray, Martin Bennett

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Citations

Aug 26, 2014·Oxidative Medicine and Cellular Longevity·Kamila SyslováPetr Kačer
Sep 26, 2014·Current Atherosclerosis Reports·Lona J Kroese, Peter G Scheffer
Dec 10, 2015·Antioxidants & Redox Signaling·Alessandro Di MinnoMatteo Nicola Dario Di Minno
May 3, 2013·Journal of Applied Toxicology : JAT·Piper Reid HuntRobert L Sprando
Mar 22, 2015·Mutation Research. Reviews in Mutation Research·Miral Dizdaroglu
Nov 20, 2014·PloS One·Irfan KhanRobert M Brosh
Jun 15, 2016·Journal of Separation Science·Agnieszka IwanowskaKrzysztof Szczubiałka
Aug 1, 2013·Biomolecular Concepts·Himadri BiswasRajagopal Chattopadhyaya
Jan 27, 2021·Free Radical Research·Chryssostomos ChatgilialogluMichael A Terzidis
May 30, 2021·Reproductive Toxicology·Mehmet Oğuz ErbağcıGül Hüray İşlekel
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michał SzewczukBolesław T Karwowski
Nov 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karolina BoguszewskaBolesław T Karwowski

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