DNA Damage Response and Metabolic Reprogramming in Health and Disease.

Trends in Genetics : TIG
Ourania ChatzidoukakiGeorge A Garinis

Abstract

Nuclear DNA damage contributes to cellular malfunction and the premature onset of age-related diseases, including cancer. Until recently, the canonical DNA damage response (DDR) was thought to represent a collection of nuclear processes that detect, signal and repair damaged DNA. However, recent evidence suggests that beyond nuclear events, the DDR rewires an intricate network of metabolic circuits, fine-tunes protein synthesis, trafficking, and secretion as well as balances growth with defense strategies in response to genotoxic insults. In this review, we discuss how the active DDR signaling mobilizes extranuclear and systemic responses to promote cellular homeostasis and organismal survival in health and disease.

Citations

Jan 27, 2021·The Journal of Investigative Dermatology·Athanasios SiametisGeorge A Garinis
Jan 12, 2021·Frontiers in Genetics·Xiaoqiao YuePing-Kun Zhou
May 28, 2021·Nature Communications·Evi GoulielmakiGeorge A Garinis

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