DNA damage response at functional and dysfunctional telomeres

Genes & Development
Maria Pia Longhese

Abstract

The ends of eukaryotic chromosomes have long been defined as structures that must avoid being detected as DNA breaks. They are protected from checkpoints, homologous recombination, end-to-end fusions, or other events that normally promote repair of intrachromosomal DNA breaks. This differentiation is thought to be the consequence of a unique organization of chromosomal ends into specialized nucleoprotein complexes called telomeres. However, it is becoming increasingly clear that proteins governing the DNA damage response are intimately involved in the regulation of telomeres, which undergo processing and structural changes that elicit a transient DNA damage response. This suggests that functional telomeres can be recognized as DNA breaks during a temporally limited window, indicating that the difference between a break and a telomere is less defined than previously assumed.

References

Dec 8, 1995·Science·L ChongT de Lange
May 3, 1996·Cell·R J WellingerV A Zakian
Jul 1, 1996·Nature Genetics·J A MetcalfeA M Taylor
Feb 20, 1997·Nature·B van Steensel, T de Lange
Nov 5, 1997·Nature Genetics·D BroccoliT de Lange
Nov 5, 1997·Nature Genetics·T BilaudE Gilson
Nov 14, 1997·Genes & Development·W E WrightJ W Shay
Feb 26, 1998·Cell·B van SteenselT de Lange
Apr 4, 1998·Molecular Biology of the Cell·M DahlenP Sunnerhagen
May 23, 1998·Science·S GravelR J Wellinger
Nov 25, 1998·Nucleic Acids Research·I Dionne, R J Wellinger
Feb 26, 1999·Science·J KarlsederT de Lange
May 25, 1999·Cell·J D GriffithT de Lange
Dec 2, 1999·Nature Genetics·S H KimJ Campisi
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·K G Murti, D M Prescott
Feb 12, 2000·Molecular and Cellular Biology·A SmogorzewskaT de Lange
May 10, 2000·Current Biology : CB·S MarcandE Gilson
Sep 14, 2000·FEBS Letters·K SongI Lee
Jan 4, 2001·Nature Genetics·S E PetersonD E Gottschling
Feb 7, 2001·The EMBO Journal·J L Muñoz-JordánJ D Griffith
Mar 7, 2001·Genes & Development·A ChandraV Lundblad

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Citations

Apr 2, 2009·Archives of Toxicology·Li Phing Liew, Chris J Norbury
Feb 1, 2012·Chromosoma·Ronald E HectorKurt W Runge
Oct 23, 2009·Nature·Stephen P Jackson, Jiri Bartek
Jul 15, 2009·Nature Cell Biology·Basheer KhadarooMichael Lisby
Jun 25, 2008·Nature Reviews. Cancer·Fabrizio d'Adda di Fagagna
Dec 22, 2011·The Journal of Biological Chemistry·Jaewon MinHyunsook Lee
Dec 11, 2008·The Journal of Biological Chemistry·Shilpa SampathiWeihang Chai
Mar 19, 2011·Bioinformatics·Jochen WeileAnil Wipat
Feb 12, 2010·Nucleic Acids Research·Gaëlle PennarunFrançois D Boussin
Dec 31, 2008·Applied and Environmental Microbiology·Gúmer PérezLucía Ramírez
Feb 23, 2012·Molecular and Cellular Biology·Marina MartinaMaria Pia Longhese
Dec 18, 2009·Gerontology·Nicolas P AndrewsCornelia M Weyand
Oct 3, 2008·Genome Biology·Huawei XinZhou Songyang
Mar 26, 2011·PLoS Genetics·Savani AnbalaganMaria Pia Longhese
Jul 15, 2011·Clinical and Experimental Gastroenterology·Claire M PayneHarris Bernstein
Jun 3, 2010·Frontiers in Bioscience (Landmark Edition)·Lakxmi Subramanian, Toru M Nakamura
Oct 15, 2013·Chromosoma·Diego BonettiMaria Pia Longhese
Jul 6, 2010·FEBS Letters·Raymund J Wellinger
Jan 19, 2016·Frontiers in Genetics·Geraldine Servant, Prescott L Deininger
Sep 24, 2009·Mutation Research·Qishen Pang, Paul R Andreassen
Apr 21, 2009·Trends in Biochemical Sciences·Eleni P Mimitou, Lorraine S Symington
Oct 1, 2015·DNA Repair·Pingping JiaWeihang Chai
Sep 19, 2009·The EMBO Journal·Jay SarthyPeter Baumann
Oct 17, 2008·The EMBO Journal·Ken-ichi NakamuraTakuro Nakagawa
May 8, 2013·The FEBS Journal·Chiou Mee KongXueying Wang
Jul 16, 2010·The EMBO Journal·Momchil D VodenicharovRaymund J Wellinger
Jul 22, 2010·The EMBO Journal·Maria Pia LongheseMichela Clerici

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