DNA-damage response control of E2F7 and E2F8.

EMBO Reports
L Panagiotis ZalmasNicholas B La Thangue

Abstract

Here, we report that the two recently identified E2F subunits, E2F7 and E2F8, are induced in cells treated with DNA-damaging agents where they have an important role in dictating the outcome of the DNA-damage response. The DNA-damage-dependent induction coincides with the binding of E2F7 and E2F8 to the promoters of certain E2F-responsive genes, most notably that of the E2F1 gene, in which E2F7 and E2F8 coexist in a DNA-binding complex. As a consequence, E2F7 and E2F8 repress E2F target genes, such as E2F1, and reducing the level of each subunit results in an increase in E2F1 expression and activity. Importantly, depletion of either E2F7 or E2F8 prevents the cell-cycle effects that occur in response to DNA damage. Thus, E2F7 and E2F8 act upstream of E2F1, and influence the ability of cells to undergo a DNA-damage response. E2F7 and E2F8, therefore, underpin the DNA-damage response.

References

Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·X Q QinP D Adams
May 17, 1996·Cell·L YamasakiN J Dyson
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·J DeGregoriJ R Nevins
Feb 2, 2002·Nature Reviews. Molecular Cell Biology·Jeffrey M Trimarchi, Jacqueline A Lees
Feb 28, 2002·The Journal of Biological Chemistry·Shunichi Kosugi, Yuko Ohashi
Apr 2, 2003·Archives of Biochemistry and Biophysics·Craig Stevens, Nicholas B La Thangue
Apr 30, 2003·Nature Cell Biology·Craig StevensNicholas B La Thangue
Jul 2, 2003·Nature Cell Biology·Nicholas B La Thangue
Sep 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Timothy C Hallstrom, Joseph R Nevins
Nov 25, 2003·The EMBO Journal·Luisa Di StefanoKristian Helin
Jul 29, 2004·DNA Repair·Craig Stevens, Nicholas B La Thangue
Jan 15, 2005·Current Biology : CB·Kobe VliegheLieven De Veylder
Jun 25, 2005·EMBO Reports·Eros Lazzerini Denchi, Kristian Helin

❮ Previous
Next ❯

Citations

Jun 19, 2010·Cell Death and Differentiation·L IngramN B La Thangue
Oct 24, 2009·Nature Reviews. Cancer·Hui-Zi ChenGustavo Leone
Feb 9, 2010·Oncogene·S MunroN B La Thangue
Sep 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tim LammensLieven De Veylder
Mar 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Cassandra J AdamsAlex N Bullock
Aug 13, 2011·The Journal of Biological Chemistry·Li-Hsin SuChin-Hung Sun
Dec 20, 2011·Nucleic Acids Research·Bart WestendorpAlain de Bruin
Jul 3, 2009·Plant Physiology·Hélène RoaMarie-Edith Chabouté
Nov 18, 2009·Molecular and Cellular Biology·Luis A MartinezAnne Chauchereau
Dec 20, 2011·Cancer Research·Anup K Biswas, David G Johnson
Jan 25, 2012·International Journal of Molecular Sciences·Mehlika Hazar-RethinamNicholas Saunders
Sep 6, 2013·Molecular Biology of the Cell·Tsvetomira IvanovaJosé Ayté
Aug 25, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Bridget C FoxDamian Marshall
Jun 23, 2009·The International Journal of Biochemistry & Cell Biology·Zhenlong WuQiang Yu
Feb 10, 2009·Trends in Cell Biology·Tim LammensLieven De Veylder
Jan 21, 2011·The Journal of Investigative Dermatology·Mehlika Hazar-RethinamNicholas A Saunders
Dec 7, 2010·The EMBO Journal·Amandine RadziejwoskiLieven De Veylder
Jul 28, 2012·EMBO Reports·Sarah J LoftusNicholas B La Thangue
Feb 14, 2012·The EMBO Journal·Er-Chieh ChoNicholas B La Thangue
Dec 7, 2010·EMBO Reports·Blanca Gómez-EscodaJosé Ayté
Feb 26, 2013·International Journal of Cancer. Journal International Du Cancer·Yatendra Kumar SatijaSanjeev Das
Oct 2, 2009·Glia·Victoria A Swiss, Patrizia Casaccia
Jul 15, 2015·Methods : a Companion to Methods in Enzymology·Peter J Pemberton-RossErik van Nimwegen
Jun 20, 2015·Journal of the National Cancer Institute·Sin-Aye ParkJa Seok Koo
Aug 27, 2013·Cell Cycle·Lykourgos-Panagiotis ZalmasNicholas B La Thangue
Aug 3, 2010·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·David Engelmann, Brigitte M Pützer
Oct 30, 2016·Cancer Medicine·Sanghoon LeeJu-Hong Jeon
May 16, 2018·Cell Death & Disease·Amanda S CouttsNicholas B La Thangue

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.