DNA damage/cGAS-triggered up-regulation of MALAT1 promotes undesirable inflammatory responses in radiotherapy of cancer.

Biochemical and Biophysical Research Communications
Chuang YuanMing Wu

Abstract

Radiotherapy is the most common strategy for treating cancer. However, the radiation-induced inflammatory responses, acute or chronic, in the normal tissues of the irradiated region may result in undesirable side effects, such as lung injury and atherosclerosis. MALAT1 is believed to function in the onset, development, progression and metastasis of various cancers. Silencing MALAT1 may be a promising treatment for rescuing cancer. Nevertheless, whether MALAT1 promotes the radiation-induced undesirable inflammatory response is still uncovered. The present study reveals that radiation-induced DNA damage triggers cGAS signaling and subsequently increases the expression of MALAT1. Overexpression of MALAT1 inhibits the function of miR146a in the suppression of STAT1, which results in the boost of adhesion molecules and eventually induces acute lung injury and atherosclerosis. Thus, silencing MALAT1 may facilitate the reduction of radiation-induced acute and chronic complications in the radiotherapy of cancer.

References

Aug 6, 2011·Stroke; a Journal of Cerebral Circulation·Chris PlummerStephen J Read
Dec 19, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Saske HovingFiona A Stewart
Mar 15, 2013·The New England Journal of Medicine·Sarah C DarbyPer Hall
May 24, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saifeng WangSongdong Meng
Jul 16, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·M E LomaxP O'Neill
May 17, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael B BartonGeoff P Delaney
Jul 19, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lars Henning SchmidtRainer Wiewrodt
Oct 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chuan JinLei Ma
Dec 21, 2017·Biochemical and Biophysical Research Communications·Ning HuangfuXiaomin Chen
Oct 26, 2018·Nature·Haipeng LiuBaoxue Ge
Jun 25, 2019·Frontiers in Immunology·Heidi HarjunpääSusanna C Fagerholm

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Citations

Mar 16, 2021·Biochemical and Biophysical Research Communications·Ming WuChuang Yuan

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