DNA dinucleotide evolution in humans: fitting theory to facts.

Genetics
A RenwickMarek Kimmel

Abstract

We examine length distributions of approximately 6000 human dinucleotide microsatellite loci, representing chromosomes 1-22, from the GDB database. Under the stepwise mutation model, results from theory and simulation are compared with the empirical data. In both constant and expanding population scenarios, a simple single-step model with parameters chosen to account for the observed variance of microsatellite lengths produces results inconsistent with the observed heterozygosity and the dispersion of length skewness. Complicating the model by allowing a variable mutation rate accounts for the homozygosity, and introducing a small probability of a large mutation step accounts for the dispersion in skewnesses. We discuss these results in light of the long-term evolution of microsatellites.

References

Aug 1, 1993·Human Molecular Genetics·J L Weber, C Wong
Dec 1, 1996·Theoretical Population Biology·M Kimmel, R Chakraborty
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·R ChakrabortyR Deka
Oct 27, 1997·American Journal of Human Genetics·J L Mountain, L L Cavalli-Sforza
Dec 16, 1997·Trends in Biochemical Sciences·R I Richards, G R Sutherland
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·D E Reich, D B Goldstein
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·G CooperW Amos
May 5, 2000·Journal of Molecular Evolution·Y ZhuJ E Strassmann
Dec 9, 2000·Molecular Biology and Evolution·J P KingR Chakraborty

❮ Previous
Next ❯

Citations

Feb 18, 2005·Genetics·Hongyan XuYun-Xin Fu
Jun 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Matthew T WebsterHans Ellegren
May 22, 2004·Nature Reviews. Genetics·Hans Ellegren
Dec 17, 2009·Molecular Biotechnology·Atul Bhargava, F F Fuentes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.