PMID: 6167537Jan 1, 1981Paper

DNA distribution of mast cell populations in growing rats

Histochemistry
L Enerbäck, I Rundquist

Abstract

The proliferation of rat peritoneal mast cells was examined under normal conditions in vivo. DNA content of individual mast cells was measured by cytofluorometry after staining with the bibenzimidazole dye Hoechst 33258. Diploid non mast cells from each rat were used as a biological standard, which resulted in small long-term variations in the method. The proportion of mast cells in the S + G2 region of the DNA distribution was about 4% for young rats (24 days old, body-weights about 60 g). It decreased in relation to body-weight, and was less than 1% for 105-day-old rats weighing 400 g. During the same growth period the total number of mast cells in the peritoneal cavity increased about 8-fold. The total number of proliferating cells, about 30,000, remained constant throughout the observation period. No evidence of polyploidization or accumulation in G2 of mast cell nuclei was found. It is concluded that peritoneal mast cells increase in number by mitotic proliferation of differentiated cells.

References

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Citations

Aug 1, 1984·In Vitro·K NorrbyP Druvefors
Nov 5, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·X J Chen, L Enerbäck
May 1, 1983·Journal of Clinical Pathology·L EnerbäckK Norrby
Oct 30, 2003·Critical Reviews in Clinical Laboratory Sciences·Finn Edler von Eyben
Jan 1, 1990·European Journal of Immunology·B M ChanA Froese
Sep 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·I RundquistU Brunk
Nov 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·K Norrby
May 1, 1983·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·K NorrbyP Druvefors
Nov 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·K NorrbyB Forsberg

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