DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes

Expert Opinion on Biological Therapy
Alesya A FokinaJean-Christophe François

Abstract

Ongoing studies on the inhibition of gene expression at the mRNA level have identified several types of specific inhibitors such as antisense oligonucleotides, small interfering RNA, ribozymes and DNAzymes (Dz). After its discovery in 1997, the 10-23 Dz (which can cleave RNA efficiently and site-specifically, has flexible design, is independent from cell mechanisms, does not require expensive chemical modifications for effective use in vivo) has been employed to downregulate a range of therapeutically important genes. Recently, 10-23 Dzs have taken their first steps into clinical trials. This review focuses predominantly on Dz applications as potential antiviral, antibacterial, anti-cancer and anti-inflammatory agents as well as for the treatment of cardiovascular disease and diseases of CNS, summarizing results of their clinical trials up to the present day. In comparison with antisense oligonucleotides and small interfering RNAs, Dzs do not usually show off-target effects due to their high specificity and lack of immunogenicity in vivo. As more results of clinical trials carried out so far are gradually becoming available, Dzs may turn out to be safe and well-tolerated therapeutics in humans. Therefore, there is a good chance...Continue Reading

References

Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P C Zamecnik, M L Stephenson
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S W Santoro, G F Joyce
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y AsahinaG Y Wu
Sep 28, 1998·Biochemistry·S W Santoro, G F Joyce
Jun 8, 1999·The Journal of Biological Chemistry·L Q SunA King
Sep 11, 1999·Annals of Neurology·L YenR G Kalb
Jan 19, 2000·Nucleic Acids Research·M J CairnsL Q Sun
Feb 15, 2001·The Biochemical Journal·R Goila, A C Banerjea
Jun 21, 2001·Biochemical and Biophysical Research Communications·C LiuP Tien
Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·P O IversenM Sioud
Oct 31, 2002·Neoplasia : an International Journal for Oncology Research·Dag R SorensenMouldy Sioud
Dec 14, 2002·Biochemical and Biophysical Research Communications·Eleni HjiantoniouLeonidas A Phylactou
Dec 26, 2002·The Journal of Biological Chemistry·Timothy A VickersBrenda F Baker
Apr 16, 2003·European Journal of Biochemistry·Jens Kurreck
Jun 6, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Samitabh Chakraborti, Akhil C Banerjea
Oct 8, 2003·Nucleic Acids Research·Steffen SchubertJens Kurreck
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Barbara Grimpe, Jerry Silver
May 6, 2004·Journal of the National Cancer Institute·Guishui ZhangLevon M Khachigian
Aug 24, 2004·Current Pharmaceutical Biotechnology·J C AchenbachY Li
Sep 28, 2004·The Hematology Journal : the Official Journal of the European Haematology Association·Majid KabuliKhalid Tobal
Feb 9, 2005·Biochemistry·Joseph M AckermannAnthony E Pegg

❮ Previous
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Citations

Sep 19, 2015·Future Medicinal Chemistry·Shujun Fu, Lun-Quan Sun
May 6, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Nataliia GuzEvgeny Katz
Jul 6, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kay MarquardtFrank Runkel
Jun 24, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pengyu LiJunlin He
Dec 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olga A KrashenininaAlya G Venyaminova
Jan 10, 2018·Medicinal Research Reviews·Changmai ChenXinjing Tang
Jul 31, 2018·Chemical Communications : Chem Comm·Hien Bao Dieu ThaiDae-Ro Ahn
May 19, 2017·Angewandte Chemie·Nicholas AnkenbruckAlexander Deiters
Aug 3, 2018·Chembiochem : a European Journal of Chemical Biology·Yu ChengCan Li
Sep 2, 2018·Biological Chemistry·Junyao DingQubo Zhu
Nov 5, 2019·Chembiochem : a European Journal of Chemical Biology·Yajun WangJohn C Chaput
Nov 3, 2017·Metallomics : Integrated Biometal Science·Wenhu Zhou, Juewen Liu
Mar 10, 2018·Beilstein Journal of Organic Chemistry·Françoise DebartJean-Jacques Vasseur
Dec 1, 2018·Nature Communications·Yajun WangJohn C Chaput
Jul 28, 2020·Quarterly Reviews of Biophysics·Ali NikoomanzarJohn C Chaput
Jun 5, 2019·Cold Spring Harbor Perspectives in Biology·Alexander I TaylorPhilipp Holliger
Feb 20, 2019·Journal of Fluorescence·Zohreh ShomaliNematollah Omidikia
Jul 25, 2018·Applied Biochemistry and Biotechnology·Elham ZokaeiSeyed Noureddin Nematollahi-Mahani
Sep 25, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Shu-Ichi NakanoNaoki Sugimoto
Sep 19, 2020·Chemical Society Reviews·Ronald Micura, Claudia Höbartner
Jan 2, 2021·European Journal of Medicinal Chemistry·Jiang LiuPeng Yu
Jan 29, 2021·Analytical and Bioanalytical Chemistry·Lin ZhuChaoyong Yang
Jan 13, 2021·Chembiochem : a European Journal of Chemical Biology·Andrey Giovanni Gomes de OliveiraDmitry M Kolpashchikov
Oct 16, 2020·Chemistry : a European Journal·Mégane DebiaisMichael Smietana
Mar 27, 2021·Nature Chemistry·Yajun WangJohn C Chaput
Apr 4, 2021·International Journal of Molecular Sciences·Haoyu XiongSarah D Diermeier
Apr 7, 2021·Angewandte Chemie·Congzhi LiuYuliang Zhao
Aug 25, 2021·Chemistry, an Asian Journal·Shi-Yi ZhangRuo-Can Qian
Oct 26, 2021·Cellular and Molecular Neurobiology·Hussein BaharlooiMaryam Azimi

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