DNA fragmentation and meiotic segregation in sperm of carriers of a chromosomal structural abnormality

Fertility and Sterility
A PerrinF Morel

Abstract

To determine the meiotic segregation and DNA fragmentation in spermatozoa of carriers of a chromosomal structural abnormality. Case series. University hospital. Thirty-seven male carriers of a chromosomal structural abnormality (21 with a balanced reciprocal translocation, 7 with a robertsonian translocation, 9 with a pericentric inversion). Meiotic segregation was analyzed by the human sperm-hamster oocyte fusion technique or by fluorescent in situ hybridization, and DNA fragmentation was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay. Relationships between abnormal sperm parameters, DNA fragmentation, and meiotic mechanisms. The average rates of chromosomally unbalanced spermatozoa were 55.22%, 14.09%, and 18.43% for reciprocal translocation, robertsonian translocation, and pericentric inversion carriers, respectively. The rates of DNA fragmentation were significantly higher in the whole group of carriers of a chromosomal structural abnormality and in each specific group than in the control group. No correlations between sperm DNA fragmentation and parameters of spermogram, age, or percentage of unbalanced chromosomal gametes were found. The DNA fragmentation rate depends solely on the...Continue Reading

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Citations

Jan 5, 2013·Journal of Assisted Reproduction and Genetics·Alexandre RouenJean-Pierre Siffroi
Jul 31, 2013·Journal of Assisted Reproduction and Genetics·Larysa Y PylypNadiya M Bilko
Mar 4, 2014·Reproductive Biomedicine Online·Xavier VendrellMiguel Ruiz-Jorro
Dec 30, 2014·Human Fertility : Journal of the British Fertility Society·Minh Huong NguyenAurore Perrin
May 15, 2013·Reproductive Biomedicine Online·M SeiringerT Ebner
Jan 15, 2011·Reproductive Biomedicine Online·A PerrinF Morel
Jul 30, 2010·Fertility and Sterility·Agustín García-PeiróJordi Benet
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Jan 5, 2011·Journal of Biomedicine & Biotechnology·A García-PeiróJ Benet
Dec 3, 2014·Fertility and Sterility·Gianpiero D PalermoZev Rosenwaks
May 20, 2017·Human Fertility : Journal of the British Fertility Society·Hossein MozdaraniAnahita Mohseni-Meybodi
Apr 30, 2015·Expert Review of Proteomics·Montserrat CodinaRafael Oliva
Nov 19, 2019·Open Medicine·Ruixue WangHongguo Zhang
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Dec 24, 2020·Best Practice & Research. Clinical Endocrinology & Metabolism·Lorena Rodrigo
Mar 9, 2021·Open Medicine·Xinyue ZhangHongguo Zhang

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