PMID: 8593583Oct 30, 1995Paper

DNA fragmentation in granular cells of human cerebellum following global ischemia

Brain Research
A HaraH Mori

Abstract

Vulnerability of human cerebellum in two autopsy cases following global brain ischemia was examined histologically by using a specific in situ nick-end labeling method for DNA breaks. In both cases, DNA fragmentation was observed in approximately one-third of the granular cells in cerebellar cortex, whereas Purkinje cells were still alive and no DNA fragmentation was recognized in the nuclei. The present study suggests that some granular cells of cerebellar cortex are more vulnerable to transient ischemia than Purkinje cells and death of granular cells is induced by an apoptotic DNA fragmentation following global brain ischemia.

Citations

Oct 3, 2002·Current Opinion in Critical Care·Marc LeoneClaude Martin
Aug 13, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A HaraH Mori
Nov 25, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·A E KingsburyO J Foster
Apr 22, 1999·Annals of Neurology·J B SchulzM A Moskowitz
Jul 21, 1999·Journal of Neurobiology·A M VincentK Maiese
Apr 28, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A M Vincent, K Maiese
Jul 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y P TangT Nabeshima
Aug 9, 2002·Journal of Cellular and Molecular Medicine·L. ZagreanB.O. Popescu
May 29, 1999·Journal of Neuroscience Research·T A KentJ R Perez-Polo
Feb 2, 1999·Experimental Cell Research·A M Vincent, K Maiese
Jan 1, 1997·Brain Research Bulletin·G CebersS Liljequist

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