DNA-Hybrid-Gated Photothermal Mesoporous Silica Nanoparticles for NIR-Responsive and Aptamer-Targeted Drug Delivery

ACS Applied Materials & Interfaces
Yuanxin ZhangJun Lin

Abstract

Near-infrared light is an attractive stimulus due to its noninvasive and deep tissue penetration. Particularly, NIR light is utilized for cancer thermotherapy and on-demand release of drugs by the disruption of the delivery carriers. Here we have prepared a novel NIR-responsive DNA-hybrid-gated nanocarrier based on mesoporous silica-coated Cu1.8S nanoparticles. Cu1.8S nanoparticles, possessing high photothermal conversion efficiency under a 980 nm laser, were chosen as photothermal agents. The mesoporous silica structure could be used for drug storage/delivery and modified with aptamer-modified GC-rich DNA-helix as gatekeepers, drug vectors, and targeting ligand. Simultaneously, the as-produced photothermal effect caused denaturation of DNA double strands, which triggered the drug release of the DNA-helix-loaded hydrophilic drug doxorubicin and mesopore-loaded hydrophobic drug curcumin, resulting in a synergistic therapeutic effect. The Cu1.8S@mSiO2 nanocomposites endocytosed by cancer cells through the aptamer-mediated mode are able to generate rational release of doxorubicin/curcumin under NIR irradiation, strongly enhancing the synergistic growth-inhibitory effect of curcumin against doxorubicin in MCF-7 cells, which is asso...Continue Reading

References

Jul 18, 1997·Science·B AntonssonJ C Martinou
Aug 28, 1998·Science·D R Green, J C Reed
Feb 21, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·K AvgoustakisD S Ithakissios
Aug 9, 2002·Biochemical Pharmacology·Songyot AnuchapreedaPorn-ngarm Limtrakul
Apr 8, 2003·Current Medicinal Chemistry. Anti-cancer Agents·M A Jordan
Oct 29, 2004·Nature Reviews. Cancer·Carl-Henrik HeldinArne Ostman
Mar 30, 2005·Biochemical Pharmacology·Jiuhong KangYuntao Zhang
May 6, 2006·Cell Death and Differentiation·L M DejeanK W Kinnally
Nov 2, 2007·Journal of Medicinal Chemistry·Ahmad SafavyJames A Bonner
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Mar 8, 2008·The Journal of Investigative Dermatology·Konstantinos G LasithiotakisFriedegund E Meier
Jan 31, 2009·Nature Reviews. Drug Discovery·Jia JiaYu Zong Chen
Feb 12, 2009·ACS Nano·Oliver EhlertThomas Nann
Mar 12, 2009·Journal of the American Chemical Society·Juan L Vivero-EscotoVictor S-Y Lin
May 21, 2009·Experimental and Molecular Pathology·Paula J BatesJohn O Trent
Sep 3, 2009·Annals of the New York Academy of Sciences·Simone ReuterMarc Diederich
Dec 18, 2009·Cardiology·Kanu ChatterjeeJoel S Karliner
Apr 12, 2011·Nature Materials·Joseph M LutherA Paul Alivisatos
Apr 23, 2011·Cell Cycle·Alexander Scarth WatsonAnna Katharina Simon
Dec 3, 2011·Annals of Biomedical Engineering·Joseph K YoungRebekah A Drezek
Mar 24, 2012·Chemical Society Reviews·Piaoping YangJun Lin
Jul 5, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gili BiskerDvir Yelin
Sep 18, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yang LiuChen Jiang
Mar 8, 2013·Journal of the American Chemical Society·Jing ZhangXian-Zheng Zhang
May 22, 2013·Journal of the American Chemical Society·Qiwei TianXiaogang Liu
Mar 29, 2014·Angewandte Chemie·Ravi V J ChariWayne C Widdison
Jun 18, 2014·Molecular Therapy. Nucleic Acids·Jiehua Zhou, John J Rossi
Jan 9, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Yinyin ChenJun Lin

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Citations

Mar 15, 2016·Biomaterials Science·Bei LiuJun Lin
May 28, 2016·Journal of Nanobiotechnology·Ewelina PiktelRobert Bucki
Feb 4, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Bastian RühleJeffrey I Zink
Jul 14, 2016·Chemistry, an Asian Journal·Xiaozhong Qu, Zhenzhong Yang
Sep 23, 2016·Chemical Reviews·Gaixia XuParas N Prasad
Jul 13, 2016·Expert Opinion on Drug Delivery·Rafael R CastilloMaría Vallet-Regí
Jan 11, 2017·Cancer Biology & Therapy·Yonglu ZhangZhanglin Zhang
Jan 21, 2017·ACS Applied Materials & Interfaces·Meysam KeshavarzKrishnan Venkatakrishnan
Mar 9, 2017·Nanoscale·Yanmei YangBengang Xing
Dec 29, 2017·Advanced Healthcare Materials·Antonia G DenkovaPablo Serra-Crespo
Feb 2, 2018·Advanced Materials·Yuezhou ZhangHongbo Zhang
Mar 23, 2019·Expert Opinion on Drug Delivery·Rafael R CastilloMaría Vallet-Regí
Feb 23, 2019·International Journal of Molecular Sciences·Rafael R Castillo, María Vallet-Regí
Feb 26, 2020·Pharmaceutical Development and Technology·Shahram Emami, Ali Shayanfar
Sep 5, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wei HuZaizai Tong
Jul 30, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Somayeh VandghanooniYadollah Omidi
Mar 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mathieu CianconeSandrine Cammas-Marion
Oct 9, 2018·Current Medicinal Chemistry·Fen HeYanfei Liu
Jun 13, 2018·Engineering in Life Sciences·Esra Ilhan-Ayisigi, Ozlem Yesil-Celiktas
Aug 26, 2019·Seminars in Cancer Biology·Sergey G KlochkovGjumrakch Aliev
Jan 28, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Can LeiTao Zou
Jan 8, 2017·Biomaterials·Leoni A Kunz-SchughartSuman Pokhrel
Jun 15, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaowei LuanYujun Song
Jul 1, 2021·Journal of Agricultural and Food Chemistry·Lujing Xu, Songbai Liu
Jul 23, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kristina ŽivojevićNikola Ž Knežević
Oct 20, 2017·Chemical Reviews·Wenpei FanXiaoyuan Chen
Oct 9, 2017·ACS Biomaterials Science & Engineering·Ranjith Kumar KankalaYu-Fang Hu

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