DNA hypomethylation of the Krüppel-like factor 11 (KLF11) gene promoter: a putative biomarker of depression comorbidity in panic disorder and of non-anxious depression?

Journal of Neural Transmission
Leonie KollertKatharina Domschke

Abstract

Panic disorder (PD) is one of the most common anxiety disorders and often occurs comorbidly with major depressive disorder (MDD). Altered methylation of the monoamine oxidase A (MAOA) gene has been implicated in the etiology of both PD and MDD. The Krüppel-like factor 11 (KLF11; alias TIEG2), an activating transcription factor of the MAOA gene, has been found to be increased in MDD, but has not yet been investigated in PD. In an effort to further delineate the effects of the KLF11-MAOA pathway in anxiety and affective disorders, KLF11 promoter methylation was analyzed via pyrosequencing of sodium bisulfite-treated DNA isolated from human peripheral blood in two independent samples of PD patients with or without comorbid MDD in a case-control design (sample 1: N = 120) as well as MDD patients with and without anxious depression (sample 2: N = 170). Additionally, in sample 1, KLF11 methylation was correlated with Beck Depression Inventory (BDI-II) scores. No overall association of KLF11 promoter methylation with PD was detected. However, PD patients with comorbid MDD showed significant hypomethylation relative to both healthy controls (p = 0.010) and PD patients without comorbid MDD (p = 0.008). Furthermore, KLF11 methylation was...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Mar 1, 1997·Brain Research. Molecular Brain Research·D BengelK P Lesch
Mar 31, 2000·Comprehensive Psychiatry·M FavaJ F Rosenbaum
Jan 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Brenda C MurphyShiva M Singh
Jun 1, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·R D GoodwinH U Wittchen
Apr 6, 2006·Archives of General Psychiatry·Ronald C KesslerEllen E Walters
Nov 3, 2007·Biochimica Et Biophysica Acta·Ananda L Roy
Jan 4, 2008·The American Journal of Psychiatry·Maurizio FavaMadhukar H Trivedi
May 9, 2008·Nature Reviews. Genetics·Miho M Suzuki, Adrian Bird
Oct 8, 2008·Journal of Psychopharmacology·K DomschkeB T Baune
Nov 7, 2008·Methods in Molecular Biology·Emelyne DejeuxJörg Tost
Aug 9, 2011·Journal of Psychiatric Research·Shabnam NohesaraHamid Mostafavi Abdolmaleky
Mar 23, 2012·The International Journal of Neuropsychopharmacology·Katharina DomschkeJürgen Deckert
Sep 6, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Elena ShumayJoanna S Fowler
Mar 2, 2013·The International Journal of Neuropsychopharmacology·Philippe A MelasCatharina Lavebratt
Jan 24, 2014·Psychological Medicine·A J BaxterH A Whiteford
Dec 17, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sharonda HarrisJun Ming Wang
Jan 28, 2015·Psychiatry Research·Philippe A Melas, Yvonne Forsell
Feb 28, 2015·Epidemiology and Psychiatric Sciences·R C KesslerM A Wilcox
Feb 6, 2017·Clinical Epigenetics·Mihoko Shimada-SugimotoTsukasa Sasaki
Sep 6, 2017·Genes, Brain, and Behavior·M A Schiele, K Domschke
Dec 19, 2017·Translational Psychiatry·Stella IuratoAngelika Erhardt
Jan 7, 2018·Journal of Human Genetics·Mihoko ShimadaTsukasa Sasaki
Sep 1, 2018·The International Journal of Neuropsychopharmacology·Miriam A SchieleKatharina Domschke
Sep 5, 2018·Methods in Molecular Biology·Matthew PoulinToshi Shioda
Sep 23, 2018·Journal of Neural Transmission·Christiane Ziegler, Katharina Domschke
Jul 30, 2019·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Miriam A SchieleKatharina Domschke
Nov 23, 2019·Translational Psychiatry·Christiane ZieglerKatharina Domschke

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
PCR

Software Mentioned

PROMO
Blood Brain DNA Methylation Comparison Tool
UCSC Genome Browser

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.