DNA interstrand cross-linking agents and their chemotherapeutic potential

Current Medicinal Chemistry
L BrulikovaP Hradil

Abstract

DNA interstrand cross-linking (ICL) agents are an important group of cytotoxic drugs with the capability of binding covalently between two strands of DNA, thereby preventing vital processes such as replication or transcription in dividing cells. In anticancer therapy however, their potential is limited due to the resistance by various mechanisms. In order to develop highly effective antitumor drugs it is necessary to study both effective ICL formations and their subsequent repair mechanisms. This review presents an overview of development over the past decade and the use of both well-known and new DNA interstrand cross-linking agents. Their potential in applications especially as anticancer chemotherapeutics in the framework of current knowledge of repair mechanisms and development of combined chemotherapy is discussed.

Citations

May 16, 2013·World Journal of Gastroenterology : WJG·Gang ChenSheng-Quan Zou
Apr 25, 2016·Neoplasia : an International Journal for Oncology Research·Chi-Wei ChenTe-Chang Lee
May 12, 2015·European Journal of Pharmacology·Vandana Srivastava, Hoyun Lee
Aug 3, 2014·Journal of Inorganic Biochemistry·Artak TovmasyanGennadi Gasparyan
Oct 6, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Olatz LarrañagaFernando P Cossío
May 21, 2014·Angewandte Chemie·Mohammad Mojibul HaqueXiaohua Peng
May 20, 2014·Organic & Biomolecular Chemistry·Ibrahim M El-DeebMark von Itzstein
Nov 20, 2018·Molecular Genetics & Genomic Medicine·Karthik Raja VelmuruganHarold R Garner
Apr 1, 2018·Applied Microbiology and Biotechnology·Xihong HeHuitu Zhang
Sep 13, 2017·Applied Microbiology and Biotechnology·Yang LiuHuitu Zhang
Feb 9, 2021·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Naji Said Aboud HadiHelga Stopper
Apr 22, 2018·Current Opinion in Pharmacology·Halley B Rycenga, David T Long

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