PMID: 26328304Sep 4, 2015Paper

DNA Mediated Vaccines Delivery Through Nanoparticles

Journal of Nanoscience and Nanotechnology
Muhammad Ali A ShahNongyue He

Abstract

Vaccination has led to the eradication of those diseases which had once claimed millions of lives worldwide; however, it is accompanied with a number of dis-advantages especially safety issues until the entry of DNA vaccines. The DNA vaccines have been emerged as the best remedy for problematic diseases being capable of producing humoral and cellular immune responses as well as the safest vaccines so far. However, the magnitude of immune responses produced in primates is lower than that in experimental animals. There are several reasons described theoretically for this limited efficacy and a number of novel approaches have been applied to boost their immune responses, e.g., use of more efficient promoters and coding optimization, addition of traditional or genetic adjuvants, electroporation, intradermal delivery and various prime-boost strategies. One of these strategies is controlled antigen administration of plasmid DNA through microspheres and nanoparticles. This approach is accompanied with a number of advantages to overcome the limitations of traditional delivery systems in terms of stability, solubility and pharmacology. Furthermore, the surface structure of a virus highly resembles with a nanoparticle because of their ge...Continue Reading

Citations

May 11, 2016·Expert Review of Vaccines·Gabriela Navarro-TovarSergio Rosales-Mendoza
Dec 28, 2018·Biotechnology & Genetic Engineering Reviews·Armando Tejeda-MansirPatricia Guerrero-Germán
Jan 8, 2020·Pharmaceutics·Michael LimMohammad Ariful Islam
Jun 6, 2020·Nanotechnology·Xiaofeng DaiKostya Ken Ostrikov
Feb 12, 2017·Pharmacology & Therapeutics·Christopher D ZahmDouglas G McNeel
Apr 11, 2021·FEMS Yeast Research·Anna Jéssica Duarte SilvaAntonio Carlos Freitas
Aug 9, 2021·Advanced Drug Delivery Reviews·Guangna LiuGuangjun Nie

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