DNA Metabarcoding Authentication of Ayurvedic Herbal Products on the European Market Raises Concerns of Quality and Fidelity

Frontiers in Plant Science
G S SeethapathyHugo J de Boer

Abstract

Ayurveda is one of the oldest systems of medicine in the world, but the growing commercial interest in Ayurveda based products has increased the incentive for adulteration and substitution within this herbal market. Fraudulent practices such as the use of undeclared fillers and use of other species of inferior quality is driven both by the increased as well as insufficient supply capacity of especially wild plant species. Developing novel strategies to exhaustively assess and monitor both the quality of raw materials and final marketed herbal products is a challenge in herbal pharmacovigilance. Seventy-nine Ayurvedic herbal products sold as tablets, capsules, powders, and extracts were randomly purchased via e-commerce and pharmacies across Europe, and DNA metabarcoding was used to assess the ability of this method to authenticate these products. Our analysis reveals that only two out of 12 single ingredient products contained only one species as labeled, eight out of 27 multiple ingredient products contained none of the species listed on the label, and the remaining 19 products contained 1 to 5 of the species listed on the label along with many other species not specified on the label. The fidelity for single ingredient produc...Continue Reading

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Citations

May 30, 2020·Journal of Food Science·Georgios LagiotisPanagiotis Madesis
Sep 10, 2020·Plants·Caroline HowardAdrian Slater
Feb 16, 2021·Frontiers in Pharmacology·Rafael M PalharesMaria G L Brandão
Jan 29, 2021·Frontiers in Pharmacology·Mihael Cristin Ichim, Hugo J de Boer
May 4, 2021·Frontiers in Pharmacology·Mihael Cristin Ichim, Anthony Booker

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Methods Mentioned

BETA
Assay
PCR

Software Mentioned

Galaxy
ClustVis
PRINSEQ
HTS Barcode Checker
BLAST
Torrent Suite

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