DNA methyl transferase inhibiting halogenated monoterpenes from the Madagascar red marine alga Portieria hornemannii

Journal of Natural Products
Eric H AndrianasoloWilliam H Gerwick

Abstract

Three new halogenated monoterpenes, 2, 3, and 4, along with the known compounds halomon (1) and two analogues, 5 and 6, were isolated from the Madagascar red marine alga Portieria hornemannii. The structures of all three new compounds were determined by NMR spectroscopy in combination with mass spectrometric data analysis. Two of these monoterpenes (1 and 2) were low micromolar inhibitors of DNA methyl transferase-1.

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Citations

Sep 29, 2007·Journal of Natural Products·Eric H AndrianasoloPaul Falkowski
Jun 24, 2008·Journal of Natural Products·Eric H AndrianasoloPaul Falkowski
Feb 6, 2008·Natural Product Reports·John W BluntMichèle R Prinsep
Aug 18, 2010·Antimicrobial Agents and Chemotherapy·Dipak MannaAnuradha Lohia
Dec 14, 2011·Marine Drugs·Dioli Ann PayoOlivier de Clerck
Aug 15, 2014·Parasitology Research·Ke-Xin YuChing-Lee Wong
Sep 24, 2015·Journal of the American Chemical Society·Cyril BucherNoah Z Burns
May 23, 2015·Environmental Science and Pollution Research International·Nadine SaulChristian E W Steinberg
Oct 5, 2012·Expert Opinion on Therapeutic Patents·Jacques FahyPaola B Arimondo
Nov 10, 2016·Marine Drugs·Bálint GálNoah Z Burns
Sep 25, 2014·Chemical Communications : Chem Comm·D Christopher BraddockMariko Whyte
Dec 18, 2018·Natural Product Reports·Florence LefrancDavid Newman
Jan 15, 2020·Current Medicinal Chemistry·Dario MatuljaDean Marković
Sep 19, 2019·Marine Drugs·Ana-Marija CikošIgor Jerković
Oct 11, 2012·ChemMedChem·Patricia García-DomínguezÁngel R de Lera
Oct 31, 2018·Marine Drugs·Djenisa H A RochaDiana C G A Pinto
Mar 5, 2015·Journal of the American Chemical Society·Dennis X HuNoah Z Burns

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